Yang and colleagues demonstrate that lipid nanoparticle-mediated precise hepatic ASGR1 base editing safely produces robust and durable lipid lowering in an LDLR-deficient mouse model of familial hypercholesterolemia. Their work further benchmarks the lipid-lowering effects of ASGR1 and ANGPTL3 editing and supports combined ASGR1/ANGPTL3 targeting for enhanced cholesterol lowering.

arXiv:2603.02266v1 Announce Type: cross Abstract: Test-Time Scaling has shown notable efficacy in addressing complex problems through scaling inference compute. However, within Large Audio-Language Models (LALMs), an unintuitive phenomenon exists: post-training models for structured reasoning trajectories results in marginal or even negative gains compared to post-training for direct answering. To investigate it, we introduce CAFE, an evaluation framework designed to precisely quantify audio reasoning errors. Evaluation results reveal LALMs struggle with perception during reasoning and encounter a critical bottleneck: reasoning performance suffers from audio perception decay as reasoning length extends. To address it, we propose MPAR$^2$, a paradigm that encourages dynamic perceptual reasoning and decomposes complex questions into perception-rich sub-problems. Leveraging reinforcement learning, MPAR$^2$ improves perception performance on CAFE from 31.74% to 63.51% and effectively mitigates perception decay, concurrently enhancing reasoning capabilities to achieve a significant 74.59% accuracy on the MMAU benchmark. Further analysis demonstrates that MPAR$^2$ reinforces LALMs to attend to audio input and dynamically adapts reasoning budget to match task complexity.