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STAT3-mediated transactivation of NOVA2 promotes lung adenocarcinoma metastasis by splicing SMAD4

Oncogene, Published online: 01 April 2026; doi:10.1038/s41388-026-03752-6

STAT3-mediated transactivation of NOVA2 promotes lung adenocarcinoma metastasis by splicing SMAD4
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Non-enzymatic function of QSOX2 directly regulates the JUNB-ITGB4 axis and enhanced resistance to osimertinib in EGFR-mutation lung adenocarcinoma

Cell Death Discovery, Published online: 01 April 2026; doi:10.1038/s41420-026-02969-4

Non-enzymatic function of QSOX2 directly regulates the JUNB-ITGB4 axis and enhanced resistance to osimertinib in EGFR-mutation lung adenocarcinoma
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CosyAccent: Duration-Controllable Accent Normalization Using Source-Synthesis Training Data

arXiv:2602.19166v1 Announce Type: cross Abstract: Accent normalization (AN) systems often struggle with unnatural outputs and undesired content distortion, stemming from both suboptimal training data and rigid duration modeling. In this paper, we propose a "source-synthesis" methodology for training data construction. By generating source L2 speech and using authentic native speech as the training target, our approach avoids learning from TTS artifacts and, crucially, requires no real L2 data in training. Alongside this data strategy, we introduce CosyAccent, a non-autoregressive model that resolves the trade-off between prosodic naturalness and duration control. CosyAccent implicitly models rhythm for flexibility yet offers explicit control over total output duration. Experiments show that, despite being trained without any real L2 speech, CosyAccent achieves significantly improved content preservation and superior naturalness compared to strong baselines trained on real-world data.
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