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AgentFugue: Agent Scaling for Long-Horizon Tasks through Collective Reasoning
Hera: Learning Long-Horizon Coordination for Device-Cloud Collaborative LLM Agents
Bridging the Semantic-Action Gap in Visual Token Pruning for Efficient VLA Inference
Ancient DNA reveals pervasive directional selection across West Eurasia
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10358-1
Analysis of 15,836 ancient West Eurasian genomes reveals hundreds of instances of directional selection, showing that sustained changes in allele frequency were widespread, rather than being rare over this period as previously assumed.China discontinues prominent journal ranking list
Nature, Published online: 14 April 2026; doi:10.1038/d41586-026-01216-1
China discontinues prominent journal ranking listStableTTA: Training-Free Test-Time Adaptation that Improves Model Accuracy on ImageNet1K to 96%
ContextDrag: Precise Drag-Based Image Editing via Context-Preserving Token Injection and Position-Aligned Attention
Agentified Assessment of Logical Reasoning Agents
Semantic Refinement with LLMs for Graph Representations
iPoster: Content-Aware Layout Generation for Interactive Poster Design via Graph-Enhanced Diffusion Models
QuestA: Expanding Reasoning Capacity in LLMs via Question Augmentation
Not All Tokens Are Created Equal: Query-Efficient Jailbreak Fuzzing for LLMs
Graph Structure Learning with Privacy Guarantees for Open Graph Data
Spatial Omics in Gastrointestinal Oncology: Recent Advances, Therapeutic Insights, and Clinical Translation
J Cancer. 2026 Jan 30;17(3):515-523. doi: 10.7150/jca.127381. eCollection 2026.
ABSTRACT
Gastrointestinal (GI) cancers remain a leading cause of cancer-related morbidity and mortality worldwide, largely due to their molecular heterogeneity, complex tumor microenvironment (TME), and variable treatment responses. In recent years, the emergence of spatially resolved omics technologies-encompassing spatial transcriptomics, proteomics, metabolomics, and epigenomics-has revolutionized the ability to interrogate tumor architecture with unprecedented resolution. These methods enable precise mapping of cellular and molecular interactions within intact tissue contexts, thereby uncovering spatially defined niches that influence tumor progression, immune evasion, and therapeutic resistance. In GI malignancies such as colorectal, gastric, and esophageal cancers, spatial omics have provided critical insights into cancer-stromal-immune crosstalk, identified predictive biomarkers for immunotherapy and targeted agents, and guided the development of novel therapeutic strategies. This review synthesizes the latest advances in spatial omics applied to GI oncology over the past five years, with an emphasis on their integration into early diagnosis, treatment stratification, and real-time monitoring of therapeutic efficacy. We also discuss current challenges, including standardization, data integration, and clinical validation, as well as future directions for incorporating spatial profiling into routine oncology practice. By bridging the gap between bench discoveries and bedside applications, spatial omics hold transformative potential for achieving truly personalized treatment in gastrointestinal cancers.
PMID:41869445 | PMC:PMC13003551 | DOI:10.7150/jca.127381