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The insulin-like growth factor 2 mRNA-binding protein 2 affects tumor cell metabolism <i>via</i> mitochondrial transporter activity and lipid alterations
Cell Death Discovery, Published online: 01 September 2026; doi:10.1038/s41420-026-03315-4
The insulin-like growth factor 2 mRNA-binding protein 2 affects tumor cell metabolism via mitochondrial transporter activity and lipid alterationsReal-time breath metabolomics as catalyst for personalized lung cancer diagnostics: prospective matched case-control trial (LUCAbreath)
Transl Lung Cancer Res. 2026 Mar 23;15(3):57. doi: 10.21037/tlcr-2025-aw-1187. Epub 2026 Mar 18.
ABSTRACT
BACKGROUND: Exhaled breath analysis offers notable advantages as a non-invasive method for obtaining biological information from lung cancer patients. However, since the 1980s, its successful translation into clinical practice has remained elusive. The primary challenges include the low concentrations of metabolites in exhaled breath, complexities in breath collection methodologies, difficulties in process standardisation, limited molecular coverage across different methods, and challenges in compound identification and in understanding their molecular origin. Comprehensive reviews by Amann et al. [2011], Hanna et al. [2018], Schmidt et al. [2023], and Vadala et al. [2023] provide holistic insights into the dynamic field of lung cancer breath research. This study aimed to evaluate the efficacy of real-time secondary electrospray ionization high-resolution mass spectrometry (SESI-HRMS) in differentiating lung cancer patients from matched controls based on breath metabolomic profiles.
METHODS: This prospective matched case-control study analysed 178 patients. The study included treatment-naive lung cancer patients and controls matched (1:1) on age, sex, and smoking status. SESI-HRMS was used for real-time breath analysis. Data processing was conducted through a validated multistep analytical framework. Statistical evaluation incorporated multivariate techniques and machine learning algorithms. High-resolution mass spectral features were assigned following the Schymanski [2014] classification, enabling the identification of distinct metabolic alterations.
RESULTS: SESI-HRMS identified 3,750 exhaled breath features. T-tests revealed 608 features with significant differences in intensity (P≤0.05) between cases and controls, of which 18 features remained significant after multiple testing correction (q≤0.05). Prediction model achieved reasonable performances. Cancer vs. controls was predicted with an accuracy of 0.75, sensitivity and specificity of 0.80 and 0.71, respectively. Functional enrichment analysis highlighted distinct metabolic pathways for different histological cancer types, including de novo fatty acid metabolism in adenocarcinoma and glucose metabolism in squamous cell carcinoma.
CONCLUSIONS: Real-time SESI-HRMS breath analysis differentiated lung cancer patients with acceptable accuracy from matched controls and provides valuable metabolic insights in lung cancer. This non-invasive approach could complement existing methods like genome profiling and low-dose computed tomography, potentially enhancing early detection and personalised treatment strategies towards a multi-omics approach. Further research is warranted to validate these preliminary findings and to refine the identification of putative breath biomarkers.
PMID:41982695 | PMC:PMC13071693 | DOI:10.21037/tlcr-2025-aw-1187
High-fidelity collisional quantum gates with fermionic atoms
Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10356-3
A robust composite pair-exchange gate based on controlled interactions of fermionic atoms in an optical superlattice demonstrates high fidelities and long Bell-state lifetimes, marking an important step towards a fully digital fermionic quantum computer.Iron Physiology and Its Impact on Atopic Diseases: An EAACI Taskforce Report
Allergy. 2026 Apr 6. doi: 10.1111/all.70325. Online ahead of print.
ABSTRACT
Iron is essential for oxygen transport, energy metabolism, and immune regulation. Yet iron deficiency is the most common micronutrient disorder across all age groups, affecting nearly one quarter of the global population. Iron deficiency triggers nutritional immunity, a host defense mechanism that withholds and redistributes iron, contributing to increased morbidity and mortality. This review outlines normal iron physiology, distribution and absorption pathways and on the consequences of deficiency across body compartments, with particular attention to type 2-driven diseases. Beyond anemia, insufficient iron availability disrupts immune homeostasis by promoting type 2 inflammation, elevating IgE, and activating mast cells and eosinophils. Regulatory macrophages, the central hub of iron cycling, adopt an inflammatory, iron-sequestering state that reinforces malabsorption and redistribution. Epidemiology studies show higher iron-deficiency risk in allergic individuals; low maternal iron or early-life iron predisposes to eczema, wheeze, and asthma, while food-allergen elimination (notably cow's milk) further worsens anemia risk. Clinical evidence indicates that restoring iron status through diet, supplementation, or fortification lowers IgE levels, improves lung function, and alleviates symptoms of rhinitis, urticaria, and asthma. Iron may therefore represent a modifiable determinant of allergic disease development and severity. Integrating iron assessment and nutritional care into allergy management may reduce disease burden and slow the progression of allergic march.
PMID:41943501 | DOI:10.1111/all.70325
An international mega-analysis of psychedelic drug effects on brain circuit function
Nature Medicine, Published online: 06 April 2026; doi:10.1038/s41591-026-04287-9
Analysis of neuroimaging datasets across five major psychedelics revealed a shared brain signature and provides a comprehensive insight into how these drugs reorganize brain architecture.Determinants of the Uptake and Frequency of Use of a Web Portal Digital Health Intervention in Patients With Type 2 Diabetes and/or Coronary Heart Disease: Secondary Analysis of a Randomized Controlled Trial
Genomic history of early dogs in Europe
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10112-7
Genome-wide analysis shows European dogs existed by 14,200 years ago, were already genetically distinct, received less Neolithic Southwest Asian admixture than humans did and contributed substantially to later European dogs.A mechanism to initiate emergency type 2 myelopoiesis
Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10256-6
Myelopoiesis in response to a parasitic worm infection and the mechanism selective to this form of parasite are revealed.