Background: The targeted application and design of digital health interventions (DHIs) require an understanding of usage determinants. Usage includes uptake (initial use) and frequency (extent of use), but it is unclear whether both components are driven by the same determinants. Objective: This study aimed to examine the determinants of uptake and frequency of use and assess whether they differ. Methods: The investigated DHI was a web portal provided in an intervention for improving disease-related self-management. This study is a secondary analysis of intervention group data from a parallel-group randomized controlled trial. Eligibility criteria were being an adult and being diagnosed with type 2 diabetes and/or coronary heart disease. Sociodemographic, psychological, and health-related variables were examined as determinants. Determinants were analyzed using simple and multiple regression models. Uptake was analyzed using logistic regression, and frequency was analyzed using negative binomial regression with robust SEs. Frequency was analyzed for those who used the DHI at least once. Except for sociodemographic variables, all other variables were standardized to a range from 0 to 1. For simple regression, inflation of the α error due to multiple testing was controlled via the approach of Benjamini and Hochberg, and for multiple regression, it was controlled via the significance of the complete multiple regression model. Results: Of 462 intervention group members, 199 (43.1%) used the web portal at least once. After controlling for inflation of the α error, simple regression for uptake yielded significant effects for higher education (B=0.56, 95% CI 0.18-0.95; =.004), openness (B=1.08, 95% CI 0.33-1.83; =.005), intention regarding physical activity (B=2.28, 95% CI 1.30-3.26;

Russian state-owned media reported that police in Russia arrested the administrator of LeakBase, a large hacking forum.

arXiv:2603.22311v1 Announce Type: new Abstract: Fluorescence-based Ca$^{2+}$-imaging is a powerful tool for studying localized neuronal activity, including miniature Synaptic Calcium Transients, providing real-time insights into synaptic activity. These transients induce only subtle changes in the fluorescence signal, often barely above baseline, which poses a significant challenge for automated synaptic transient detection and segmentation. Detecting astronomical transients similarly requires efficient algorithms that will remain robust over a large field of view with varying noise properties. We leverage techniques used in astronomical transient detection for miniature Synaptic Calcium Transient detection in fluorescence microscopy. We present Astro-BEATS, an automatic miniature Synaptic Calcium Transient segmentation algorithm that incorporates image estimation and source-finding techniques used in astronomy and designed for Ca$^{2+}$-imaging videos. Astro-BEATS outperforms current threshold-based approaches for synaptic Ca$^{2+}$ transient detection and segmentation. The produced segmentation masks can be used to train a supervised deep learning algorithm for improved synaptic Ca$^{2+}$ transient detection in Ca$^{2+}$-imaging data. The speed of Astro-BEATS and its applicability to previously unseen datasets without re-optimization makes it particularly useful for generating training datasets for deep learning-based approaches.

arXiv:2603.22359v1 Announce Type: new Abstract: Current AI agent frameworks commit early to a single interaction protocol, a fixed tool integration strategy, and static user models, limiting their deployment across diverse interaction paradigms. To address these constraints, we introduce STEM Agent (Self-adapting, Tool-enabled, Extensible, Multi-agent), a modular architecture inspired by biological pluripotency in which an undifferentiated agent core differentiates into specialized protocol handlers, tool bindings, and memory subsystems that compose into a fully functioning AI system. The framework unifies five interoperability protocols (A2A, AG-UI, A2UI, UCP, and AP2) behind a single gateway, introduces a Caller Profiler that continuously learns user preferences across more than twenty behavioral dimensions, externalizes all domain capabilities through the Model Context Protocol (MCP), and implements a biologically inspired skills acquisition system in which recurring interaction patterns crystallize into reusable agent skills through a maturation lifecycle analogous to cell differentiation. Complementing these capabilities, the memory system incorporates consolidation mechanisms, including episodic pruning, semantic deduplication, and pattern extraction, designed for sub-linear growth under sustained interaction. A comprehensive 413-test suite validates protocol handler behavior and component integration across all five architectural layers, completing in under three seconds.

arXiv:2603.22558v1 Announce Type: new Abstract: Generating synthetic populations from aggregate statistics is a core component of microsimulation, agent-based modeling, policy analysis, and privacy-preserving data release. Beyond classical census marginals, many applications require matching heterogeneous unary, binary, and ternary constraints derived from surveys, expert knowledge, or automatically extracted descriptions. Constructing populations that satisfy such multi-way constraints simultaneously poses a significant computational challenge. We consider populations where each individual is described by categorical attributes and the target is a collection of global frequency constraints over attribute combinations. Exact formulations scale poorly as the number and arity of constraints increase, especially when the constraints are numerous and overlapping. Grounded in methods from statistical physics, we propose a maximum-entropy relaxation of this problem. Multi-way cardinality constraints are matched in expectation rather than exactly, yielding an exponential-family distribution over complete population assignments and a convex optimization problem over Lagrange multipliers. We evaluate the approach on NPORS-derived scaling benchmarks with 4 to 40 attributes and compare it primarily against generalized raking. The results show that MaxEnt becomes increasingly advantageous as the number of attributes and ternary interactions grows, while raking remains competitive on smaller, lower-arity instances.

arXiv:2603.22619v1 Announce Type: new Abstract: LLMs often generate seemingly valid answers to flawed or ill-posed inputs. This is not due to missing knowledge: under discriminative prompting, the same models can mostly identify such issues, yet fail to reflect this in standard generative responses. This reveals a fundamental know-act gap between discriminative recognition and generative behavior. Prior work largely characterizes this issue in narrow settings, such as math word problems or question answering, with limited focus on how to integrate these two modes. In this work, we present a comprehensive analysis using FaultyScience, a newly constructed large-scale, cross-disciplinary benchmark of faulty scientific questions. We show that the gap is pervasive and stems from token-level autoregression, which entangles task selection (validate vs. answer) with content generation, preventing discriminative knowledge from being utilized. To address this, we propose DeIllusionLLM, a task-level autoregressive framework that explicitly models this decision. Through self-distillation, the model unifies discriminative judgment and generative reasoning within a single backbone. Empirically, DeIllusionLLM substantially reduces answer-despite-error failures under natural prompting while maintaining general reasoning performance, demonstrating that self-distillation is an effective and scalable solution for bridging the discriminative-generative know-act gap

arXiv:2603.23433v1 Announce Type: new Abstract: Nudges are subtle changes to the way choices are presented to human decision-makers (e.g., opt-in vs. opt-out by default) that shift behavior without restricting options or changing incentives. As AI agents increasingly make decisions in the same environments as humans, the presentation of choices may be optimized for machines as well as people. We introduce mecha-nudges: changes to how choices are presented that systematically influence AI agents without degrading the decision environment for humans. To formalize mecha-nudges, we combine the Bayesian persuasion framework with V-usable information, a generalization of Shannon information that is observer-relative. This yields a common scale (bits of usable information) for comparing a wide range of interventions, contexts, and models. Applying our framework to product listings on Etsy -- a global marketplace for independent sellers -- we find that following ChatGPT's release, listings have significantly more machine-usable information about product selection, consistent with systematic mecha-nudging.

arXiv:2603.22299v1 Announce Type: cross Abstract: Large language models (LLMs) are often confidently wrong, making reliable uncertainty estimation (UE) essential. Output-based heuristics are cheap but brittle, while probing internal representations is effective yet high-dimensional and hard to transfer. We propose a compact, per-instance UE method that scores cross-layer agreement patterns in internal representations using a single forward pass. Across three models, our method matches probing in-distribution, with mean diagonal differences of at most $-1.8$ AUPRC percentage points and $+4.9$ Brier score points. Under cross-dataset transfer, it consistently outperforms probing, achieving off-diagonal gains up to $+2.86$ AUPRC and $+21.02$ Brier points. Under 4-bit weight-only quantization, it remains robust, improving over probing by $+1.94$ AUPRC points and $+5.33$ Brier points on average. Beyond performance, examining specific layer--layer interactions reveals differences in how disparate models encode uncertainty. Altogether, our UE method offers a lightweight, compact means to capture transferable uncertainty in LLMs.

arXiv:2603.22326v1 Announce Type: cross Abstract: Decision support systems are essential for maintaining grid stability in low-carbon power systems, such as wind power plants, by providing real-time alerts to control room operators regarding potential events, including Wind Power Ramp Events (WPREs). These early warnings enable the timely initiation of more detailed system stability assessments and preventive actions. However, forecasting these events is challenging due to the inherent class imbalance in WPRE datasets, where ramp events are less frequent (typically less than 15\% of observed events) compared to normal conditions. Ignoring this characteristic undermines the performance of conventional machine learning models, which often favor the majority class. This paper introduces a novel methodology for WPRE forecasting as a multivariate time series classification task and proposes a data preprocessing strategy that extracts features from recent power observations and masks unavailable ramp information, making it integrable with traditional real-time ramp identification tools. Particularly, the proposed methodology combines majority-class undersampling and ensemble learning to enhance wind ramp event forecasting under class imbalance. Numerical simulations conducted on a real-world dataset demonstrate the superiority of our approach, achieving over 85% accuracy and 88% weighted F1 score, outperforming benchmark classifiers.

arXiv:2603.22364v1 Announce Type: cross Abstract: Diffusion models have achieved state-of-the-art performance in generative modeling, but their success often relies heavily on classifier-free guidance (CFG), an inference-time heuristic that modifies the sampling trajectory. From a theoretical perspective, diffusion models trained with standard denoising score matching (DSM) are expected to recover the target data distribution, raising the question of why inference-time guidance is necessary in practice. In this work, we ask whether the DSM training objective can be modified in a principled manner such that standard reverse-time sampling, without inference-time guidance, yields effects comparable to CFG. We identify insufficient inter-class separation as a key limitation of standard diffusion models. To address this, we propose MCLR, a principled alignment objective that explicitly maximizes inter-class likelihood-ratios during training. Models fine-tuned with MCLR exhibit CFG-like improvements under standard sampling, achieving comparable qualitative and quantitative gains without requiring inference-time guidance. Beyond empirical benefits, we provide a theoretical result showing that the CFG-guided score is exactly the optimal solution to a weighted MCLR objective. This establishes a formal equivalence between classifier-free guidance and alignment-based objectives, offering a mechanistic interpretation of CFG.

arXiv:2603.22479v1 Announce Type: cross Abstract: Defining a constructive process to build general capabilities for language models in an automatic manner is considered an open problem in artificial intelligence. Towards this, we consider the problem of building a curriculum of tasks that grows a model via relevant skill discovery. We provide a concrete framework for this task, using a family of tasks called cross-entropy games, which we postulate is universal in a suitable sense. We show that if it is possible to grow the curriculum for relevant skill discovery by iterating a greedy optimization algorithm, then, under natural assumptions, there is essentially only one meta-objective possible (up to a few hyperparameters). We call the resulting process cognitive training. We postulate that, given sufficiently capable language models as players and meta-samplers and sufficient training time, cognitive training provides a principled way to relevant skill discovery; and hence to the extent general capabilities are achievable via greedy curriculum learning, cognitive training would be a solution.

arXiv:2603.22519v1 Announce Type: cross Abstract: Textual Large Language Models (LLMs) provide a simple and familiar interface: a string of text is used for both input and output. However, the information conveyed to an LLM often has a richer structure and semantics, which is not conveyed in a string. For example, most prompts contain both instructions ("Summarize this paper into a paragraph") and data (the paper to summarize), but these are usually not distinguished when passed to the model. This can lead to model confusion and security risks, such as prompt injection attacks. This work addresses this shortcoming by introducing an LLM-native mark-up language, LLMON (LLM Object Notation, pronounced "Lemon"), that enables the structure and semantic metadata of the text to be communicated in a natural way to an LLM. This information can then be used during model training, model prompting, and inference implementation, leading to improvements in model accuracy, safety, and security. This is analogous to how programming language types can be used for many purposes, such as static checking, code generation, dynamic checking, and IDE highlighting. We discuss the general design requirements of an LLM-native markup language, introduce the LLMON markup language and show how it meets these design requirements, describe how the information contained in a LLMON artifact can benefit model training and inference implementation, and provide some preliminary empirical evidence of its value for both of these use cases. We also discuss broader issues and research opportunities that are enabled with an LLM-native approach.

arXiv:2603.22770v1 Announce Type: cross Abstract: The deployment of deep neural networks (DNNs) in safety-critical edge environments necessitates robustness against hardware-induced bit-flip errors. While empirical studies indicate that reducing numerical precision can improve fault tolerance, the theoretical basis of this phenomenon remains underexplored. In this work, we study resilience as a structural property of neural architectures rather than solely as a property of a dataset-specific trained solution. By deriving the expected squared error (MSE) under independent parameter bit flips across multiple numerical formats and layer primitives, we show that lower precision, higher sparsity, bounded activations, and shallow depth are consistently favored under this corruption model. We then argue that logic and lookup-based neural networks realize the joint limit of these design trends. Through ablation studies on the MLPerf Tiny benchmark suite, we show that the observed empirical trends are consistent with the theoretical predictions, and that LUT-based models remain highly stable in corruption regimes where standard floating-point models fail sharply. Furthermore, we identify a novel even-layer recovery effect unique to logic-based architectures and analyze the structural conditions under which it emerges. Overall, our results suggest that shifting from continuous arithmetic weights to discrete Boolean lookups can provide a favorable accuracy-resilience trade-off for hardware fault tolerance.

arXiv:2603.23047v1 Announce Type: cross Abstract: Retrieval-Augmented Generation (RAG) fine-tuning has shown substantial improvements over vanilla RAG, yet most studies target document question answering and often rely on standard NLP metrics that can obscure factual differences. We evaluate RAG fine-tuning for long-form text generation in electronic design automation, adapting a 7B model under five context augmentation strategies with varying retrieval conditions. We introduce TriFEX, a human-validated, triple-based evaluation pipeline that attributes generated claims to their origin-user query, context and reference-and propose Parametric Knowledge Precision (PKP), which isolates internalized knowledge by filtering out claims leaked in the prompt. We show that ROUGE and BERTScore fail to detect factual differences that our triple-based evaluation reveals. Additionally, we demonstrate that an existing metric for knowledge internalization is retrieva-sensitive, with about 75% of its cross-condition variance driven by changes in the rate at which internal knowledge is expressed (PR), rather than by changes in its actual correctness (PKP). The fine-tuned 7B variants outperform a 72B baseline on most metrics, further showing generalization across conditions and on a related benchmark. These results underscore the limitations of available metrics in RAG evaluation and show that smaller models could be reasonably well adapted to specialized tasks for cost-efficient, on-premises deployment.

arXiv:2603.23279v1 Announce Type: cross Abstract: The rapid diffusion of large language models and the growth in their capability has enabled the emergence of online environments populated by autonomous AI agents that interact through natural language. These platforms provide a novel empirical setting for studying collective dynamics among artificial agents. In this paper we analyze the interaction network of Moltbook, a social platform composed entirely of LLM based agents, using tools from network science. The dataset comprises 39,924 users, 235,572 posts, and 1,540,238 comments collected through web scraping. We construct a directed weighted network in which nodes represent agents and edges represent commenting interactions. Our analysis reveals strongly heterogeneous connectivity patterns characterized by heavy tailed degree and activity distributions. At the mesoscale, the network exhibits a pronounced core periphery organization in which a very small structural core (0.9% of nodes) concentrates a large fraction of connectivity. Robustness experiments show that the network is relatively resilient to random node removal but highly vulnerable to targeted attacks on highly connected nodes, particularly those with high out degree. These findings indicate that the interaction structure of AI agent social systems may develop strong centralization and structural fragility, providing new insights into the collective organization of LLM native social environments.

arXiv:2510.23421v2 Announce Type: replace-cross Abstract: The foundation model industry exhibits unprecedented concentration in critical inputs: semiconductors, energy infrastructure, elite talent, capital, and training data. Despite extensive sectoral analyses, no comprehensive framework exists for assessing overall industrial vulnerability. We develop the Artificial Intelligence Industrial Vulnerability Index (AIIVI) grounded in O-Ring production theory, recognizing that foundation model production requires simultaneous availability of non-substitutable inputs. Given extreme data opacity and rapid technological evolution, we implement a validated human-in-the-loop methodology using large language models to systematically extract indicators from dispersed grey literature, with complete human verification of all outputs. Applied to six state-of-the-art foundation model developers, AIIVI equals 0.82, indicating extreme vulnerability driven by compute infrastructure (0.85) and energy systems (0.90). While industrial policy currently emphasizes semiconductor capacity, energy infrastructure represents the emerging binding constraint. This methodology proves applicable to other fast-evolving, opaque industries where traditional data sources are inadequate.

arXiv:2603.10845v2 Announce Type: replace-cross Abstract: Human Presence Detection (HPD) is key to enable intelligent power management and security features in everyday devices. In this paper we propose the first HPD solution that leverages monostatic Wi-Fi sensing and detects user position using only the built-in Wi-Fi hardware of a device, with no need for external devices, access points, or additional sensors. In contrast, existing HPD solutions for laptops require external dedicated sensors which add cost and complexity, or rely on camera-based approaches that introduce significant privacy concerns. We herewith introduce the Range-Filtered Doppler Spectrum (RF-DS), a novel Wi-Fi sensing technique for presence estimation that enables both range-selective and temporally windowed detection of user presence. By applying targeted range-area filtering in the Channel Impulse Response (CIR) domain before Doppler analysis, our method focuses processing on task-relevant spatial zones, significantly reducing computational complexity. In addition, the use of temporal windows in the spectrum domain provides greater estimator stability compared to conventional 2D Range-Doppler detectors. Furthermore, we propose an adaptive multi-rate processing framework that dynamically adjusts Channel State Information (CSI) sampling rates-operating at low frame rates (10Hz) during idle periods and high rates (100Hz) only when motion is detected. To our knowledge, this is the first low-complexity solution for occupancy detection using monostatic Wi-Fi sensing on a built-in Wi-Fi network interface controller (NIC) of a commercial off-the-shelf laptop that requires no external network infrastructure or specialized sensors. Our solution can scale across different environments and devices without calibration or retraining.

Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10112-7

Genome-wide analysis shows European dogs existed by 14,200 years ago, were already genetically distinct, received less Neolithic Southwest Asian admixture than humans did and contributed substantially to later European dogs.

Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10266-4

Insights into the mechanism by which phosphatidylserine functions as a non-classical inhibitory molecule during T cell exhaustion, and how phosphatidylserine-targeting antibodies enhance T cell responses are explored.

Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10306-z

A study in Drosophilareveals a mechanism of non-homeostatic hunger and its critical relevance for memory consolidation.