arXiv:2512.04733v2 Announce Type: replace-cross Abstract: End-to-end autonomous driving (AD) systems increasingly adopt vision-language-action (VLA) models, yet they typically ignore the passenger's emotional state, which is central to comfort and AD acceptance. We introduce Open-Domain End-to-End (OD-E2E) autonomous driving, where an autonomous vehicle (AV) must interpret free-form natural-language commands, infer the emotion, and plan a physically feasible trajectory. We propose E3AD, an emotion-aware VLA framework that augments semantic understanding with two cognitively inspired components: a continuous Valenc-Arousal-Dominance (VAD) emotion model that captures tone and urgency from language, and a dual-pathway spatial reasoning module that fuses egocentric and allocentric views for human-like spatial cognition. A consistency-oriented training scheme, combining modality pretraining with preference-based alignment, further enforces coherence between emotional intent and driving actions. Across real-world datasets, E3AD improves visual grounding and waypoint planning and achieves state-of-the-art (SOTA) VAD correlation for emotion estimation. These evaluation results show that injecting emotion into VLA-style driving yields more human-aligned grounding, planning, and feedback.

arXiv:2604.08213v2 Announce Type: replace-cross Abstract: High-quality source-target image pairs with precise editing instructions are essential for instruction-guided image editing, yet constructing such training triplets at scale remains costly. Recent pipelines often rely on vision-language models to synthesize editing instructions automatically, but we find that strong VLMs still struggle to describe visual transformations between image pairs. In particular, they exhibit three recurring failure modes: orientation inconsistency, viewpoint ambiguity, and missing fine-grained attributes. In a human evaluation on 400 image pairs, several open-source VLM baselines produce critical-error rates above 47\%, making many synthesized instructions unsuitable for downstream training. To address this, we propose EditCaption, a two-stage post-training pipeline for image editing instruction synthesis. First, we construct a 100K supervised fine-tuning dataset through GLM-based auto-captioning, EditScore filtering, and human refinement. Second, we collect 10K human-annotated preference pairs, where each rejected instruction is labeled with its primary error type and severity. Based on this dataset, we propose Hardness-Adaptive Error-Aware DPO (HAE-DPO), a task-adapted DPO objective that introduces an adaptive margin based on human-labeled severity, failure-mode type, and reference-model hardness. Experiments across three benchmarks demonstrate that our 235B model with SFT+HAE-DPO achieves state-of-the-art performance among open-source and closed models, scoring 4.720 on Eval-400, 4.672 on HQ-Edit, and 4.651 on ByteMorph-Bench -- surpassing Gemini-3-Pro on all three. Human evaluation confirms critical error rates drop from 47.75\% to 17.50\%, with correct rates improving from 41.75\% to 70.25\%, surpassing Gemini-3-Pro (66.00\%).

arXiv:2604.23728v2 Announce Type: replace-cross Abstract: Recent advances in autonomous driving have motivated research on pedestrian intention prediction, which aims to infer future crossing decisions and actions by modeling temporal dynamics, social interactions, and environmental context. However, existing studies remain constrained by oversimplified multi-agent interaction patterns, opaque reasoning logic, and a lack of global consistency in behavioral predictions, which compromise both robustness and interpretability. In this work, we propose ESIA (Energy-based Spatiotemporal Interaction-Aware framework), a novel Conditional Random Field (CRF)-based paradigm. We cast the intention prediction task as a structured prediction problem over a unified graph-based representation, treating pedestrians and the environment as spatiotemporal nodes. To characterize their distinct roles, we assign unary potentials to nodes to capture individual intentions, and pairwise potentials to edges to encode social and environmental interactions. These potentials are integrated into a unified global energy function to ensure scene-level consistency across behavioral predictions. To further constrain inference without ground-truth supervision, we introduce structural consistency terms to penalize logical contradictions. This optimization is efficiently solved via a novel Unary-Seeded Simulated Annealing (U-SSA) algorithm, which leverages high-confidence unary priors to rapidly converge to a high-quality solution. Extensive experiments on standard benchmarks demonstrate that ESIA achieves state-of-the-art performance with improved interpretability over existing methods.

Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10572-x

A fungal long non-coding RNA from Magnaporthe oryzae translocates into rice cells to sequester a host microRNA that normally represses PKR1, a negative immunity regulator, thereby facilitating infection and revealing a widespread RNA-based pathogen–host interaction mechanism.

arXiv:2604.01670v1 Announce Type: new Abstract: While long-term memory is essential for intelligent agents to maintain consistent historical awareness, the accumulation of extensive interaction data often leads to performance bottlenecks. Naive storage expansion increases retrieval noise and computational latency, overwhelming the reasoning capacity of models deployed on constrained personal devices. To address this, we propose Hierarchical Memory Orchestration (HMO), a framework that organizes interaction history into a three-tiered directory driven by user-centric contextual relevance. Our system maintains a compact primary cache, coupling recent and pivotal memories with an evolving user profile to ensure agent reasoning remains aligned with individual behavioral traits. This primary cache is complemented by a high-priority secondary layer, both of which are managed within a global archive of the full interaction history. Crucially, the user persona dictates memory redistribution across this hierarchy, promoting records mapped to long-term patterns toward more active tiers while relegating less relevant information. This targeted orchestration surfaces historical knowledge precisely when needed while maintaining a lean and efficient active search space. Evaluations on multiple benchmarks achieve state-of-the-art performance. Real-world deployments in ecosystems like OpenClaw demonstrate that HMO significantly enhances agent fluidity and personalization.

arXiv:2510.16635v2 Announce Type: replace-cross Abstract: Prompt optimization has become a practical way to improve the performance of Large Language Models (LLMs) without retraining. However, most existing frameworks treat evaluation as a black box, relying solely on outcome scores without explaining why prompts succeed or fail. Moreover, they involve repetitive trial-and-error refinements that remain implicit, offering limited interpretability or actionable guidance for systematic improvement. In this paper, we propose MA-SAPO: a new Multi-Agent Reasoning for Score Aware Prompt Optimization framework that links evaluation outcomes directly to targeted refinements. Specifically, in the Training Phase, multiple agents interpret evaluation scores, diagnose weaknesses, and generate concrete revision directives, which are stored as reusable reasoning assets. In the Test Phase, an analyzer agent retrieves relevant exemplars and assets for a new prompt, and a refiner agent applies evidence-based edits to improve the prompt and its response. By grounding optimization in structured reasoning, MA-SAPO ensures edits are interpretable, auditable, and controllable. Experiments on the HelpSteer1/2 benchmarks show that our framework consistently outperforms single-pass prompting, retrieval-augmented generation, and prior multi-agent methods across multiple evaluation metrics.

arXiv:2603.22362v1 Announce Type: cross Abstract: Full-waveform inversion (FWI) estimates physical parameters in the wave equation from limited measurements and has been widely applied in geophysical exploration, medical imaging, and non-destructive testing. Conventional FWI methods are limited by their notorious sensitivity to the accuracy of the initial models. Recent progress in continuous representation FWI (CR-FWI) demonstrates that representing parameter models with a coordinate-based neural network, such as implicit neural representation (INR), can mitigate the dependence on initial models. However, its underlying mechanism remains unclear, and INR-based FWI shows slower high-frequency convergence. In this work, we investigate the general CR-FWI framework and develop a unified theoretical understanding by extending the neural tangent kernel (NTK) for FWI to establish a wave-based NTK framework. Unlike standard NTK, our analysis reveals that wave-based NTK is not constant, both at initialization and during training, due to the inherent nonlinearity of FWI. We further show that the eigenvalue decay behavior of the wave-based NTK can explain why CR-FWI alleviates the dependency on initial models and shows slower high-frequency convergence. Building on these insights, we propose several CR-FWI methods with tailored eigenvalue decay properties for FWI, including a novel hybrid representation combining INR and multi-resolution grid (termed IG-FWI) that achieves a more balanced trade-off between robustness and high-frequency convergence rate. Applications in geophysical exploration on Marmousi, 2D SEG/EAGE Salt and Overthrust, 2004 BP model, and the more realistic 2014 Chevron models show the superior performance of our proposed methods compared to conventional FWI and existing INR-based FWI methods.

arXiv:2602.02050v3 Announce Type: replace Abstract: Tool-using agents based on Large Language Models (LLMs) excel in tasks such as mathematical reasoning and multi-hop question answering. However, in long trajectories, agents often trigger excessive and low-quality tool calls, increasing latency and degrading inference performance, making managing tool-use behavior challenging. In this work, we conduct entropy-based pilot experiments and observe a strong positive correlation between entropy reduction and high-quality tool calls. Building on this finding, we propose using entropy reduction as a supervisory signal and design two reward strategies to address the differing needs of optimizing tool-use behavior. Sparse outcome rewards provide coarse, trajectory-level guidance to improve efficiency, while dense process rewards offer fine-grained supervision to enhance performance. Experiments across diverse domains show that both reward designs improve tool-use behavior: the former reduces tool calls by 72.07% compared to the average of baselines, while the latter improves performance by 22.27%. These results position entropy reduction as a key mechanism for enhancing tool-use behavior, enabling agents to be more adaptive in real-world applications.

arXiv:2512.03454v3 Announce Type: replace-cross Abstract: Interpreting natural-language commands to localize target objects is critical for autonomous driving (AD). Existing visual grounding (VG) methods for autonomous vehicles (AVs) typically struggle with ambiguous, context-dependent instructions, as they lack reasoning over 3D spatial relations and anticipated scene evolution. Grounded in the principles of world models, we propose ThinkDeeper, a framework that reasons about future spatial states before making grounding decisions. At its core is a Spatial-Aware World Model (SA-WM) that learns to reason ahead by distilling the current scene into a command-aware latent state and rolling out a sequence of future latent states, providing forward-looking cues for disambiguation. Complementing this, a hypergraph-guided decoder then hierarchically fuses these states with the multimodal input, capturing higher-order spatial dependencies for robust localization. In addition, we present DrivePilot, a multi-source VG dataset in AD, featuring semantic annotations generated by a Retrieval-Augmented Generation (RAG) and Chain-of-Thought (CoT)-prompted LLM pipeline. Extensive evaluations on six benchmarks, ThinkDeeper ranks #1 on the Talk2Car leaderboard and surpasses state-of-the-art baselines on DrivePilot, MoCAD, and RefCOCO/+/g benchmarks. Notably, it shows strong robustness and efficiency in challenging scenes (long-text, multi-agent, ambiguity) and retains superior performance even when trained on 50% of the data.

arXiv:2603.03677v1 Announce Type: cross Abstract: Large language models (LLMs) have advanced medical dialogue systems, yet psychiatric consultation poses substantially higher demands due to subjective ambiguity and comorbidity complexity: an agent must continuously extract psychopathological cues from incomplete and inconsistent patient reports in multi-turn interactions and perform rigorous differential diagnostic reasoning. However, existing methods face two fundamental challenges. First, without criteria-grounded clinical supports, they are prone to unsupported clinical assertions when symptoms are atypical or underspecified. Second, in multi-turn interactions, they struggle to mitigate inquiry drift (off-topic or low-yield questioning) and optimize questioning strategies. To address these challenges, we propose MIND, a unified inquiry--diagnosis reinforcement learning framework for psychiatric consultation. Specifically, we build a Criteria-Grounded Psychiatric Reasoning Bank (PRB) that summarizes dialogue context into clinical retrieval states, retrieves semantically similar reference consultations, and distills reusable criteria-grounded clinical supports to guide criteria-aligned inquiry and reasoning. Building on this foundation, MIND enforces explicit clinical reasoning with rubric-based process rewards to provide fine-grained supervision over intermediate decision steps, and incorporates a value-aware trajectory rectification mechanism to jointly improve information acquisition and diagnostic decision-making across turns. Extensive experiments demonstrate that MIND consistently outperforms strong baselines in diagnostic accuracy, empathetic interaction quality, interpretability, and generalization.

arXiv:2510.25232v2 Announce Type: replace Abstract: Psychiatric comorbidity is clinically significant yet challenging due to the complexity of multiple co-occurring disorders. To address this, we develop a novel approach integrating synthetic patient electronic medical record (EMR) construction and multi-agent diagnostic dialogue generation. We create 502 synthetic EMRs for common comorbid conditions using a pipeline that ensures clinical relevance and diversity. Our multi-agent framework transfers the clinical interview protocol into a hierarchical state machine and context tree, supporting over 130 diagnostic states while maintaining clinical standards. Through this rigorous process, we construct PsyCoTalk, the first large-scale dialogue dataset supporting comorbidity, containing 3,000 multi-turn diagnostic dialogues validated by psychiatrists. This dataset enhances diagnostic accuracy and treatment planning, offering a valuable resource for psychiatric comorbidity research. Compared to real-world clinical transcripts, PsyCoTalk exhibits high structural and linguistic fidelity in terms of dialogue length, token distribution, and diagnostic reasoning strategies. Licensed psychiatrists confirm the realism and diagnostic validity of the dialogues. This dataset enables the development and evaluation of models capable of multi-disorder psychiatric screening in a single conversational pass.

arXiv:2506.11087v3 Announce Type: replace-cross Abstract: Supervised Fine-Tuning (SFT) empowers Large Language Models (LLMs) with exceptional performance on specialized tasks, but it yields dense, high-dimensional delta parameters that pose severe storage and distribution challenges. Singular Value Decomposition (SVD)-based compression offers a compact representation for such delta parameters, but existing methods adopt heuristic quantization without clarifying underlying mechanisms, leading to poor generalizability. In this work, we propose PrinMix, a rigorous SVD-based framework that models quantization as an optimization problem, grounding the design in mathematical mechanisms. We first theoretically derive quantization error and identify a key singular-value-dominated scaling mechanism, which mathematically proves the necessity of mix-precision quantization. We then model the quantization scheme as a 0/1 Integer Linear Programming (ILP) problem, which yields optimal bit-budget-constrained solutions without empirical assumptions. Furthermore, PrinMix integrates a Reconstruction Target Correction (RTC) method to compensate for errors from the $\mathbf{V}$-then-$\mathbf{U}$ sequential quantization process. Extensive experiments confirm PrinMix performs well: for 7B LLMs, PrinMix outperforms SOTA Delta-CoMe on challenging benchmarks by 22.3% on AIME2024 and 6.1% on GQA.

arXiv:2509.25275v3 Announce Type: replace-cross Abstract: Bridge models have been investigated in speech enhancement but are mostly single-task, with constrained general speech restoration (GSR) capability. In this work, we propose VoiceBridge, a one-step latent bridge model (LBM) for GSR, capable of efficiently reconstructing 48 kHz fullband speech from diverse distortions. To inherit the advantages of data-domain bridge models, we design an energy-preserving variational autoencoder, enhancing the waveform-latent space alignment over varying energy levels. By compressing waveform into continuous latent representations, VoiceBridge models~\textit{various} GSR tasks with a~\textit{single} latent-to-latent generative process backed by a scalable transformer. To alleviate the challenge of reconstructing the high-quality target from distinctively different low-quality priors, we propose a joint neural prior for GSR, uniformly reducing the burden of the LBM in diverse tasks. Building upon these designs, we further investigate bridge training objective by jointly tuning LBM, decoder and discriminator together, transforming the model from a denoiser to generator and enabling \textit{one-step GSR without distillation}. Extensive validation across in-domain (\textit{e.g.}, denoising and super-resolution) and out-of-domain tasks (\textit{e.g.}, refining synthesized speech) and datasets demonstrates the superior performance of VoiceBridge. Demos: https://VoiceBridgedemo.github.io/.