❌

Normal view

Received — 27 May 2026 ⏭

Spatial multi-omics technologies in gastric cancer: applications and advances

✇Omics in Gastric
By: Qianqian Liu · Haowen Liu · Jing Lv · Jiashuo Li · Guangtan Du · Wensheng Qiu · Shasha Wang
30 April 2026 at 18:00

Front Immunol. 2026 Apr 14;17:1767512. doi: 10.3389/fimmu.2026.1767512. eCollection 2026.

ABSTRACT

Gastric cancer (GC) is plagued by profound intratumoral heterogeneity and a complex tumor microenvironment (TME), which are the core obstacles to precise diagnosis and treatment. Conventional bulk multi-omics technologies average molecular signals across tissues, thus masking cellular heterogeneity; single-cell multi-omics resolves cellular diversity but dissociates cells from their native spatial context, leading to the loss of critical information on intercellular crosstalk and molecular spatial distribution. These limitations result in an incomplete understanding of GC pathogenesis and TME regulatory networks. Spatial multi-omics technologies, integrating genomics, transcriptomics, proteomics, and metabolomics with high-resolution spatial localization, address these key scientific problems by preserving the native tissue architecture and elucidating the spatiotemporal dynamics of molecular and cellular events in GC. This review systematically synthesizes the latest advances in the application of four major spatial multi-omics modalities in GC research over the past 15 years, with a critical evaluation of the technical performance, methodological shortcomings, and clinical translation potential of existing studies. Unlike previous reviews that only summarize research findings, this work uniquely integrates technical principles, mechanistic discoveries, and clinical translation of spatial multi-omics in GC, deeply analyzes the practical barriers to clinical application, and systematically elaborates the integration of spatial multi-omics with artificial intelligence (AI). We also identify unresolved challenges in the field and propose future development directions, providing a comprehensive and in-depth reference for the advancement of GC precision medicine based on spatial multi-omics.

PMID:42058209 | PMC:PMC13120937 | DOI:10.3389/fimmu.2026.1767512

Received — 8 April 2026 ⏭

RDFace: A Benchmark Dataset for Rare Disease Facial Image Analysis under Extreme Data Scarcity and Phenotype-Aware Synthetic Generation

✇cs.AI, q-bio.NC updates on arXiv.org
By: Ganlin Feng · Yuxi Long · Hafsa Ali · Erin Lou · Fahad Butt · Qian Liu · Yang Wang · Pingzhao Hu
7 April 2026 at 12:00
arXiv:2604.03454v1 Announce Type: cross Abstract: Rare diseases often manifest with distinctive facial phenotypes in children, offering valuable diagnostic cues for clinicians and AI-assisted screening systems. However, progress in this field is severely limited by the scarcity of curated, ethically sourced facial data and the high similarity among phenotypes across different conditions. To address these challenges, we introduce RDFace, a curated benchmark dataset comprising 456 pediatric facial images spanning 103 rare genetic conditions (average 4.4 samples per condition). Each ethically verified image is paired with standardized metadata. RDFace enables the development and evaluation of data-efficient AI models for rare disease diagnosis under real-world low-data constraints. We benchmark multiple pretrained vision backbones using cross-validation and explore synthetic augmentation with DreamBooth and FastGAN. Generated images are filtered via facial landmark similarity to maintain phenotype fidelity and merged with real data, improving diagnostic accuracy by up to 13.7% in ultra-low-data regimes. To assess semantic validity, phenotype descriptions generated by a vision-language model from real and synthetic images achieve a report similarity score of 0.84. RDFace establishes a transparent, benchmark-ready dataset for equitable rare disease AI research and presents a scalable framework for evaluating both diagnostic performance and the integrity of synthetic medical imagery.
Received — 2 April 2026 ⏭
Received — 5 March 2026 ⏭

When Scaling Fails: Mitigating Audio Perception Decay of LALMs via Multi-Step Perception-Aware Reasoning

✇cs.AI, q-bio.NC updates on arXiv.org
By: Ruixiang Mao · Xiangnan Ma · Dan Chen · Ziming Zhu · Yuan Ge · Aokai Hao · Haishu Zhao · Yifu Huo · Qing Yang · Kaiyan Chang · Xiaoqian Liu · Chenglong Wang · Qiaozhi He · Tong Xiao · Jingbo Zhu
4 March 2026 at 13:00
arXiv:2603.02266v1 Announce Type: cross Abstract: Test-Time Scaling has shown notable efficacy in addressing complex problems through scaling inference compute. However, within Large Audio-Language Models (LALMs), an unintuitive phenomenon exists: post-training models for structured reasoning trajectories results in marginal or even negative gains compared to post-training for direct answering. To investigate it, we introduce CAFE, an evaluation framework designed to precisely quantify audio reasoning errors. Evaluation results reveal LALMs struggle with perception during reasoning and encounter a critical bottleneck: reasoning performance suffers from audio perception decay as reasoning length extends. To address it, we propose MPAR$^2$, a paradigm that encourages dynamic perceptual reasoning and decomposes complex questions into perception-rich sub-problems. Leveraging reinforcement learning, MPAR$^2$ improves perception performance on CAFE from 31.74% to 63.51% and effectively mitigates perception decay, concurrently enhancing reasoning capabilities to achieve a significant 74.59% accuracy on the MMAU benchmark. Further analysis demonstrates that MPAR$^2$ reinforces LALMs to attend to audio input and dynamically adapts reasoning budget to match task complexity.
There are no more articles
❌