Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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L2IR: Revealing Latent Intent in Graph Fraud Detection
arXiv:2605.26040v1 Announce Type: new Abstract: Graph fraud detection has long depended on Graph Neural Networks (GNNs) to propagate and aggregate information across relational data. A critical obstacle in practice, however, is that fraudsters frequently disguise themselves by forging numerous connections with benign users, causing fraud signals to be progressively diluted during neighborhood aggregation and undermining detection reliability. While recent efforts have used Large Language Models
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cs.AI, q-bio.NC updates on arXiv.org
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Agent Learning via Early Experience
arXiv:2510.08558v3 Announce Type: replace Abstract: A long-term goal of language agents is to learn and improve through their own experience, ultimately outperforming humans in complex, real-world tasks. However, training agents from experience data with reinforcement learning remains difficult in many environments, which either lack verifiable rewards (e.g., websites) or require inefficient long-horizon rollouts (e.g., multi-turn tool use). As a result, most current agents rely on supervised f
Agent Learning via Early Experience
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cs.AI, q-bio.NC updates on arXiv.org
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ProcCtrlBench: Evaluating Process-Level Defects and Control Preservation in LLM Coding Agents
arXiv:2605.20251v4 Announce Type: replace-cross Abstract: Existing benchmarks for LLM coding agents primarily evaluate final outcomes. While useful for measuring overall capability, these metrics provide limited visibility and often miss defects that arise during execution. We present ProcCtrlBench, a benchmark for execution-process evaluation in LLM coding agents. ProcCtrlBench organizes recurrent execution defects into a reusable ontology covering 11 defect types in 4 categories, and evaluate
ProcCtrlBench: Evaluating Process-Level Defects and Control Preservation in LLM Coding Agents
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Nature Biotechnology - Issue - nature.com science feeds
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A framework for building a synthetic cell from the SynCell Asia Initiative
Nature Biotechnology, Published online: 26 May 2026; doi:10.1038/s41587-026-03153-wBuilding a living cell from scratch requires overcoming a bottleneck that has remained unresolved despite decades of progress: orchestrating the spatiotemporal integration of core functional modules. To tackle this barrier, the SynCell Asia Initiative outlines a strategy for developing core functional modules followed by their systems-level integration through the establishment of a centralized, artificial intelli
A framework for building a synthetic cell from the SynCell Asia Initiative
Nature Biotechnology, Published online: 26 May 2026; doi:10.1038/s41587-026-03153-w
Building a living cell from scratch requires overcoming a bottleneck that has remained unresolved despite decades of progress: orchestrating the spatiotemporal integration of core functional modules. To tackle this barrier, the SynCell Asia Initiative outlines a strategy for developing core functional modules followed by their systems-level integration through the establishment of a centralized, artificial intelligence (AI)-driven biofoundry.-
Nature - Issue - nature.com science feeds
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Electric dipole moment drives the dynamics of the TNFR1 complex I signalosome
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10304-1Long-range interactions mediated by protein electric dipole moments have a role in driving the assembly and disassembly of super-signalling complex I for promoting NF-κB signalling.
Electric dipole moment drives the dynamics of the TNFR1 complex I signalosome
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10304-1
Long-range interactions mediated by protein electric dipole moments have a role in driving the assembly and disassembly of super-signalling complex I for promoting NF-κB signalling.-
Omics In Lung
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Integrative Multi-omics Analysis of Buti Huatan Tang in Chronic Obstructive Pulmonary Disease
J Vis Exp. 2026 Mar 13;(229). doi: 10.3791/70383.ABSTRACTThis study utilized a multi-omics and computational biology framework to investigate the therapeutic potential of the Traditional Chinese Medicine (TCM) formula Buti Huatan Tang (BTHTT) against chronic obstructive pulmonary disease (COPD). Significant physiological improvements were observed in a rat model following BTHTT intervention. Histological analysis showed a reversal of lung pathological damage, while biochemical assays, and transc
Integrative Multi-omics Analysis of Buti Huatan Tang in Chronic Obstructive Pulmonary Disease
J Vis Exp. 2026 Mar 13;(229). doi: 10.3791/70383.
ABSTRACT
This study utilized a multi-omics and computational biology framework to investigate the therapeutic potential of the Traditional Chinese Medicine (TCM) formula Buti Huatan Tang (BTHTT) against chronic obstructive pulmonary disease (COPD). Significant physiological improvements were observed in a rat model following BTHTT intervention. Histological analysis showed a reversal of lung pathological damage, while biochemical assays, and transcriptomics confirmed the normalization of IL-1β and IL-1R2 levels. Additionally, metabolic profiling revealed that BTHTT corrected disruptions in T3 and T4 thyroid hormone levels. A negative correlation was observed between the IL-1β/IL-1R2 axis and these thyroid hormones, indicating that their regulation is associated with the formula's therapeutic effect. Beyond direct measurements, machine learning algorithms identified ten COPD signature genes from clinical databases. Pathway enrichment analysis suggests that BTHTT may act through cytokine-cytokine-receptor interactions and thyroid hormone synthesis pathways. Furthermore, while 283 components were identified in vivo, compounds such as tanshinone IIA and cryptotanshinone are currently considered candidate active substances. Their role as primary drivers is supported by a model in which they stably bind to IL-1R2; this inference is based on molecular docking and molecular dynamics (MD) simulations rather than direct experimental isolation. Overall, the data support a model in which BTHTT exerts a multi-target effect on COPD by modulating inflammation and metabolic homeostasis. This integrated approach provides a refined scientific basis for the clinical application of BTHTT and highlights specific pathways for future experimental validation.
PMID:41911070 | DOI:10.3791/70383
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(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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Integrative Multi-omics Analysis of Buti Huatan Tang in Chronic Obstructive Pulmonary Disease
J Vis Exp. 2026 Mar 13;(229). doi: 10.3791/70383.ABSTRACTThis study utilized a multi-omics and computational biology framework to investigate the therapeutic potential of the Traditional Chinese Medicine (TCM) formula Buti Huatan Tang (BTHTT) against chronic obstructive pulmonary disease (COPD). Significant physiological improvements were observed in a rat model following BTHTT intervention. Histological analysis showed a reversal of lung pathological damage, while biochemical assays, and transc
Integrative Multi-omics Analysis of Buti Huatan Tang in Chronic Obstructive Pulmonary Disease
J Vis Exp. 2026 Mar 13;(229). doi: 10.3791/70383.
ABSTRACT
This study utilized a multi-omics and computational biology framework to investigate the therapeutic potential of the Traditional Chinese Medicine (TCM) formula Buti Huatan Tang (BTHTT) against chronic obstructive pulmonary disease (COPD). Significant physiological improvements were observed in a rat model following BTHTT intervention. Histological analysis showed a reversal of lung pathological damage, while biochemical assays, and transcriptomics confirmed the normalization of IL-1β and IL-1R2 levels. Additionally, metabolic profiling revealed that BTHTT corrected disruptions in T3 and T4 thyroid hormone levels. A negative correlation was observed between the IL-1β/IL-1R2 axis and these thyroid hormones, indicating that their regulation is associated with the formula's therapeutic effect. Beyond direct measurements, machine learning algorithms identified ten COPD signature genes from clinical databases. Pathway enrichment analysis suggests that BTHTT may act through cytokine-cytokine-receptor interactions and thyroid hormone synthesis pathways. Furthermore, while 283 components were identified in vivo, compounds such as tanshinone IIA and cryptotanshinone are currently considered candidate active substances. Their role as primary drivers is supported by a model in which they stably bind to IL-1R2; this inference is based on molecular docking and molecular dynamics (MD) simulations rather than direct experimental isolation. Overall, the data support a model in which BTHTT exerts a multi-target effect on COPD by modulating inflammation and metabolic homeostasis. This integrated approach provides a refined scientific basis for the clinical application of BTHTT and highlights specific pathways for future experimental validation.
PMID:41911070 | DOI:10.3791/70383
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cs.AI, q-bio.NC updates on arXiv.org
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DreamAudio: Customized Text-to-Audio Generation with Diffusion Models
arXiv:2509.06027v2 Announce Type: replace-cross Abstract: With the development of large-scale diffusion-based and language-modeling-based generative models, impressive progress has been achieved in text-to-audio generation. Despite producing high-quality outputs, existing text-to-audio models mainly aim to generate semantically aligned sound and fall short of controlling fine-grained acoustic characteristics of specific sounds. As a result, users who need specific sound content may find it diff
DreamAudio: Customized Text-to-Audio Generation with Diffusion Models
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cs.AI, q-bio.NC updates on arXiv.org
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Deep Expert Injection for Anchoring Retinal VLMs with Domain-Specific Knowledge
arXiv:2603.07131v1 Announce Type: cross Abstract: Large Vision Language Models (LVLMs) show immense potential for automated ophthalmic diagnosis. However, their clinical deployment is severely hindered by lacking domain-specific knowledge. In this work, we identify two structural deficiencies hindering reliable medical reasoning: 1) the Perception Gap, where general-purpose visual encoders fail to resolve fine-grained pathological cues (e.g., microaneurysms); and 2) the Reasoning Gap, where spa
Deep Expert Injection for Anchoring Retinal VLMs with Domain-Specific Knowledge
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Oncogene - Issue - nature.com science feeds
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Arginine methylation-dependent stabilization of SUV39H1 promotes breast cancer growth
Oncogene, Published online: 07 March 2026; doi:10.1038/s41388-026-03712-0Arginine methylation-dependent stabilization of SUV39H1 promotes breast cancer growth
Arginine methylation-dependent stabilization of SUV39H1 promotes breast cancer growth
Oncogene, Published online: 07 March 2026; doi:10.1038/s41388-026-03712-0
Arginine methylation-dependent stabilization of SUV39H1 promotes breast cancer growth-
cs.AI, q-bio.NC updates on arXiv.org
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Pretrained Vision-Language-Action Models are Surprisingly Resistant to Forgetting in Continual Learning
arXiv:2603.03818v1 Announce Type: cross Abstract: Continual learning is a long-standing challenge in robot policy learning, where a policy must acquire new skills over time without catastrophically forgetting previously learned ones. While prior work has extensively studied continual learning in relatively small behavior cloning (BC) policy models trained from scratch, its behavior in modern large-scale pretrained Vision-Language-Action (VLA) models remains underexplored. In this work, we found
Pretrained Vision-Language-Action Models are Surprisingly Resistant to Forgetting in Continual Learning
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cs.AI, q-bio.NC updates on arXiv.org
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ToolRLA: Multiplicative Reward Decomposition for Tool-Integrated Agents
arXiv:2603.01620v2 Announce Type: replace Abstract: Tool-integrated agents that interleave reasoning with API calls are promising for complex tasks, yet aligning them for high-stakes, domain-specific deployment remains challenging: existing reinforcement learning approaches rely on coarse binary rewards that cannot distinguish tool selection errors from malformed parameters. We present ToolRLA, a three-stage post-training pipeline (SFT $\rightarrow$ GRPO $\rightarrow$ DPO) for domain-specific t
ToolRLA: Multiplicative Reward Decomposition for Tool-Integrated Agents
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cs.AI, q-bio.NC updates on arXiv.org
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Vision-Zero: Scalable VLM Self-Improvement via Strategic Gamified Self-Play
arXiv:2509.25541v2 Announce Type: replace-cross Abstract: Although reinforcement learning (RL) has emerged as a promising approach for improving vision-language models (VLMs) and multimodal large language models (MLLMs), current methods rely heavily on manually curated datasets and costly human verification, which limits scalable self-improvement in multimodal systems. To address this challenge, we propose Vision-Zero, a label-free, domain-agnostic multi-agent self-play framework for self-evolv
Vision-Zero: Scalable VLM Self-Improvement via Strategic Gamified Self-Play
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cs.AI, q-bio.NC updates on arXiv.org
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Improving Discrete Optimisation Via Decoupled Straight-Through Estimator
arXiv:2410.13331v2 Announce Type: replace-cross Abstract: The Straight-Through Estimator (STE) is the dominant method for training neural networks with discrete variables, enabling gradient-based optimisation by routing gradients through a differentiable surrogate. However, existing STE variants conflate two fundamentally distinct concerns: forward-pass stochasticity, which controls exploration and latent space utilisation, and backward-pass gradient dispersion i.e how learning signals are dist
Improving Discrete Optimisation Via Decoupled Straight-Through Estimator
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cs.AI, q-bio.NC updates on arXiv.org
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Step 3.5 Flash: Open Frontier-Level Intelligence with 11B Active Parameters
arXiv:2602.10604v2 Announce Type: replace-cross Abstract: We introduce Step 3.5 Flash, a sparse Mixture-of-Experts (MoE) model that bridges frontier-level agentic intelligence and computational efficiency. We focus on what matters most when building agents: sharp reasoning and fast, reliable execution. Step 3.5 Flash pairs a 196B-parameter foundation with 11B active parameters for efficient inference. It is optimized with interleaved 3:1 sliding-window/full attention and Multi-Token Prediction
Step 3.5 Flash: Open Frontier-Level Intelligence with 11B Active Parameters
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cs.AI, q-bio.NC updates on arXiv.org
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Cautious Optimizers: Improving Training with One Line of Code
arXiv:2411.16085v4 Announce Type: replace-cross Abstract: AdamW has been the default optimizer for transformer pretraining. For many years, our community searched for faster and more stable optimizers with only constrained positive outcomes. In this work, we propose a \textbf{one-line modification in Pytorch} to any momentum-based optimizer, which we rename cautious optimizer, e.g. C-AdamW and C-Lion. Our theoretical result shows that this modification preserves Adam's Hamiltonian function and