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Reliable Near-Field Multi-User Positioning Informed by Two-Stage MUSIC

arXiv:2609.09409v1 Announce Type: cross Abstract: Near-field localization is a promising technique for high-resolution multi-user positioning in future wireless systems, but its performance is often degraded by scattering-induced coherent propagation. Existing near-field localization methods, which require separate parameter estimation and path/source association, suffer from high computation overhead and accumulated errors, and usually do not provide any guarantee on reliability. In this paper, we propose \emph{MUSIC-Net}, an end-to-end near-field positioning deep learning (DL) framework informed by two-stage MUltiple SIgnal Classification (MUSIC) in mixed line-of-sight (LoS) and non-LoS (NLoS) multi-path scenarios, which embeds the two-stage MUSIC objects into training to isolate the LoS-related signal subspace and to identify a surrogate distance. The proposed framework directly recovers multi-user positions without the need for involved NLoS parameter estimation or path/source association. Furthermore, we introduce split conformal prediction (SCP) to move beyond point-estimation-based positioning towards statistically guaranteed (confidence) set estimation for all users. Numerical results show that the proposed MUSIC-Net achieves lower mean positioning error (MPER) than existing benchmarks and yields tighter SCP-calibrated prediction regions, demonstrating both accurate LoS localization and efficient uncertainty quantification (UQ) in coherent multi-path environments.

An operational perturbation proteomics-based virtual cell model

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11001-9

Temporal protein-abundance measurements from systematically perturbed breast cancer cell lines were generated to develop ProteinTalks, a virtual cell model that functions as an operational tool for diverse drug discovery tasks.

CAFs shape the immunosuppressive microenvironment of pancreatic cancer through the Lin28b-STING Axis

Nat Commun. 2026 Aug 7;17(1):9491. doi: 10.1038/s41467-026-76495-3.

ABSTRACT

Cancer-associated fibroblasts comprise diverse functionally distinct cellular subsets, with certain subpopulations exerting pivotal influence in shaping the pancreatic cancer immune microenvironment. Here we show that Lin28b+ cancer-associated fibroblasts contribute to establishing an immunologically cold tumor microenvironment in pancreatic ductal adenocarcinoma. Mechanistically, Lin28b directly binds to STING mRNA and promotes its degradation, thereby suppressing STING expression and downstream type I interferon signaling. Loss of Lin28b in cancer-associated fibroblasts activates the cGAS-STING-interferon signaling cascade, enhancing dendritic cell antigen presentation and CD8+ T cell cytotoxic function. Importantly, genetic inhibition of Lin28b in cancer-associated fibroblasts enhances sensitivity to anti-PD-L1 immune checkpoint blockade therapy. These findings reveal that targeting the Lin28b-STING axis represents a promising therapeutic strategy for overcoming the intrinsic resistance of pancreatic ductal adenocarcinoma to immunotherapy.

PMID:42693143 | PMC:PMC13542369 | DOI:10.1038/s41467-026-76495-3

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