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Neural-Quantum-States Impurity Solver for Quantum Embedding Problems
FCMBench: The First Large-scale Financial Credit Multimodal Benchmark for Real-world Applications
BitDance: Scaling Autoregressive Generative Models with Binary Tokens
FNDC1 Competitively Binds Gbeta2 to Suppress the beta-Catenin-Destruction Complex and Promote Gastric Cancer Malignancy
FASEB J. 2026 Mar 31;40(6):e71634. doi: 10.1096/fj.202503587R.
ABSTRACT
Gastric cancer (GC) is a leading cause of cancer-related deaths and has high recurrence rate. Although fibronectin domain-containing protein 1 (FNDC1) is implicated in GC progression, its molecular mechanisms remain unclear. Multi-omics analyses (TCGA, GEO datasets) were used to assess FNDC1 expression and clinical correlation. In vitro (cell proliferation, invasion, EMT markers) and in vivo (xenograft) experiments, combined with molecular assays (Co-IP, WB, ChIP), explored FNDC1's function and mechanism. FNDC1 was significantly upregulated in GC, correlating with advanced clinicopathological features and poor prognosis. Knockdown of FNDC1 suppressed GC cell proliferation, invasion, and metastasis by inhibiting EMT and Wnt/Ξ²-catenin signaling. Mechanistically, FNDC1 competitively bound the WD5 domain (residues 224-254) of GΞ²2, disrupting GΞ²Ξ³-Dvl1 interaction. This prevented Dvl1 degradation, promoted Axin1 ubiquitination, and destabilized the Ξ²-catenin-destruction complex (GSK3 Ξ²-APC-Axin1), leading to Ξ²-catenin accumulation and Wnt pathway activation. FNDC1 drives GC malignancy by targeting the GΞ²2-Dvl1 axis to activate Wnt/Ξ²-catenin signaling, suggesting FNDC1 as a novel prognostic biomarker and therapeutic target.
PMID:41808415 | PMC:PMC12976582 | DOI:10.1096/fj.202503587R
Deconstructing Multimodal Mathematical Reasoning: Towards a Unified Perception-Alignment-Reasoning Paradigm
"Better Ask for Forgiveness than Permission": Practices and Policies of AI Disclosure in Freelance Work
Towards Lightweight Adaptation of Speech Enhancement Models in Real-World Environments
\$OneMillion-Bench: How Far are Language Agents from Human Experts?
MMTU: A Massive Multi-Task Table Understanding and Reasoning Benchmark
Oscillatory shear stress-driven endothelial-to-mesenchymal transition: a critical mechanical signal transduction mechanism in atherosclerosis progression
Cell Death Discovery, Published online: 10 March 2026; doi:10.1038/s41420-026-03000-6
Oscillatory shear stress-driven endothelial-to-mesenchymal transition: a critical mechanical signal transduction mechanism in atherosclerosis progression