Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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Cognition on Graph: Navigating Massive Knowledge Space via Cognitive Cycles and Bidirectional Graph-Text Synergy
arXiv:2609.12791v1 Announce Type: cross Abstract: Retrieval-Augmented Generation (RAG) has empowered Large Language Models (LLMs) to tackle knowledge-intensive tasks. However, navigating global, heterogeneous knowledge bases (large-scale knowledge graphs and text corpora) for complex reasoning remains a challenge. Existing methods typically employ reactive, graph-driven exploration strategies, which blindly follow graph topology without adapting to the question context or evolving exploration p
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cs.AI, q-bio.NC updates on arXiv.org
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EEGBind: Detecting Source-Level Interictal Epileptiform Discharges via EEG-Centric Multimodal Binding
arXiv:2609.09728v1 Announce Type: cross Abstract: Source-level analysis of interictal epileptiform discharges (IEDs) is relevant to presurgical evaluation and treatment planning because it helps characterize where epileptiform activity is likely to arise. Beyond detecting whether an IED is present, this setting requires assigning IED-positive activity to clinically meaningful brain-region categories. This setting is challenging because source-region evidence in short electroencephalography (EEG
EEGBind: Detecting Source-Level Interictal Epileptiform Discharges via EEG-Centric Multimodal Binding
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cs.AI, q-bio.NC updates on arXiv.org
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Generative AI for Analysts
arXiv:2512.19705v2 Announce Type: replace-cross Abstract: We study how generative artificial intelligence (GenAI) reshapes financial analysts' information production. Using the 2023 integration of GenAI into FACTSET as a plausibly exogenous change in AI access, we find that FACTSET-associated reports become markedly richer--featuring 26% more distinct information sources, 24% broader topical coverage, and 21% more analytical methods--while also improving timeliness. However, these gains do not
Generative AI for Analysts
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Pulmonary nodule
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Integrated single-cell and bulk RNA sequencing reveals novel biomarkers of invasive adenocarcinoma subtypes in lung adenocarcinoma
Transl Cancer Res. 2026 Apr 30;15(4):314. doi: 10.21037/tcr-2025-aw-2503. Epub 2026 Mar 20.ABSTRACTBACKGROUND: Lung adenocarcinoma (LUAD) is one of the most common lung cancer subtypes worldwide, and its aggressive subtype invasive adenocarcinoma (IAC) has low survival rates. The precise identification of IAC is vital for the clinical diagnosis and treatment. The purpose of this study is to identify novel biomarkers for LUAD using single-cell and bulk RNA sequencing, so as to provide theoretical
Integrated single-cell and bulk RNA sequencing reveals novel biomarkers of invasive adenocarcinoma subtypes in lung adenocarcinoma
Transl Cancer Res. 2026 Apr 30;15(4):314. doi: 10.21037/tcr-2025-aw-2503. Epub 2026 Mar 20.
ABSTRACT
BACKGROUND: Lung adenocarcinoma (LUAD) is one of the most common lung cancer subtypes worldwide, and its aggressive subtype invasive adenocarcinoma (IAC) has low survival rates. The precise identification of IAC is vital for the clinical diagnosis and treatment. The purpose of this study is to identify novel biomarkers for LUAD using single-cell and bulk RNA sequencing, so as to provide theoretical basis and practical support for the diagnosis, treatment and prognosis evaluation of lung invasive adenocarcinoma.
METHODS: We employed a combination of transcriptomic analysis and single-cell analysis to investigate the molecular characteristics and immune microenvironment of four subtypes of LUAD, including atypical adenomatous hyperplasia (AAH), adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), and IAC, with the aim of screening for biomarkers to differentiate pre-invasive lesions from invasive lesions.
RESULTS: Transcriptomic and single-cell analyses revealed that IAC subtypes demonstrated the most substantial molecular differences, particularly in immune cell infiltration and immune-related gene expression. Three genes-CD27, TIGIT, and TNFRSF18-that were significantly upregulated in IAC, predominantly expressed in immune cells and closely linked to immune regulatory pathways. We further analyzed T cell subpopulations in the IAC subtype and explored the expression of transcription factors (TFs) corresponding to these three genes, revealing their critical roles in immune cell function. Additionally, communication between T cells and other cells showed significantly enhanced signaling pathways, particularly those related to immune co-stimulatory molecules and inflammation pathways. Immunohistochemical validation of clinical samples showed that these three genes have high diagnostic value in IAC subtypes. These findings establish a crucial biological foundation for diagnosis, classification, and immunotherapy of LUAD, which contributes to the development of individualized treatment strategies.
CONCLUSIONS: This study identifies a three-gene signature (CD27, TIGIT, and TNFRSF18) that not only distinguishes invasive from pre-invasive LUAD with high precision by capturing the immune checkpoint disequilibrium characteristic of IAC, but also provides a clinically actionable biomarker panel for preoperative diagnosis and personalized immunotherapy strategies.
PMID:42180871 | PMC:PMC13190665 | DOI:10.21037/tcr-2025-aw-2503
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(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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Bibliometric analysis of lung cancer organoid research: trends and emerging areas of study
J Thorac Dis. 2026 Apr 30;18(4):406. doi: 10.21037/jtd-2026-0547. Epub 2026 Apr 27.ABSTRACTBACKGROUND: Lung cancer remains the leading cause of cancer-related mortality worldwide, posing a substantial global health burden. Despite advances in early detection, molecular profiling, and targeted therapies, patient outcomes remain unsatisfactory due to tumor heterogeneity, therapeutic resistance, and the lack of reliable preclinical models. In recent years, lung cancer organoids (LCOs), patient-deri
Bibliometric analysis of lung cancer organoid research: trends and emerging areas of study
J Thorac Dis. 2026 Apr 30;18(4):406. doi: 10.21037/jtd-2026-0547. Epub 2026 Apr 27.
ABSTRACT
BACKGROUND: Lung cancer remains the leading cause of cancer-related mortality worldwide, posing a substantial global health burden. Despite advances in early detection, molecular profiling, and targeted therapies, patient outcomes remain unsatisfactory due to tumor heterogeneity, therapeutic resistance, and the lack of reliable preclinical models. In recent years, lung cancer organoids (LCOs), patient-derived three-dimensional (3D) culture systems, have demonstrated the ability to preserve the histological architecture and genomic features of primary tumors more faithfully than conventional models, making them a promising platform for translational research and precision medicine. This study aims to quantitatively evaluate the global research output, identify major contributors and collaboration patterns, and systematically uncover research hotspots and emerging trends in the field of LCOs through bibliometric analysis.
METHODS: A systematic bibliometric analysis was conducted using publications on LCOs retrieved from the Web of Science Core Collection (WoSCC). Articles published between 2015 and 2024 were included. A total of 356 publications were analyzed. Publication outputs, country and institutional contributions, collaboration networks, and keyword co-occurrence were evaluated using Bibliometrix (R package), VOSviewer, and CiteSpace.
RESULTS: The number of publications on LCOs has increased steadily over the past decade, reflecting growing research interest and technological advancement. China and the United States were identified as the leading contributors, accounting for the majority of publications, while Germany, South Korea, and Japan also demonstrated strong research capacity and active collaboration. Keyword and thematic analyses revealed several major research hotspots, including personalized medicine, drug response and resistance mechanisms, tumor microenvironment modeling, and immune-related interactions. Burst keyword analysis further identified emerging trends, such as co-culture systems, immunotherapy evaluation, and the integration of LCOs with high-throughput screening and multi-omics approaches.
CONCLUSIONS: LCOs have evolved into a versatile platform bridging basic research and clinical applications in lung cancer. This study provides a comprehensive overview of the current research landscape and highlights emerging directions in the field. Future research should focus on methodological standardization, optimization of organoid construction and evaluation, integration with multi-omics and immune models, and strengthened international collaboration to facilitate clinical translation and improve patient outcomes.
PMID:42182656 | PMC:PMC13190222 | DOI:10.21037/jtd-2026-0547
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Omics In Lung
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Bibliometric analysis of lung cancer organoid research: trends and emerging areas of study
J Thorac Dis. 2026 Apr 30;18(4):406. doi: 10.21037/jtd-2026-0547. Epub 2026 Apr 27.ABSTRACTBACKGROUND: Lung cancer remains the leading cause of cancer-related mortality worldwide, posing a substantial global health burden. Despite advances in early detection, molecular profiling, and targeted therapies, patient outcomes remain unsatisfactory due to tumor heterogeneity, therapeutic resistance, and the lack of reliable preclinical models. In recent years, lung cancer organoids (LCOs), patient-deri
Bibliometric analysis of lung cancer organoid research: trends and emerging areas of study
J Thorac Dis. 2026 Apr 30;18(4):406. doi: 10.21037/jtd-2026-0547. Epub 2026 Apr 27.
ABSTRACT
BACKGROUND: Lung cancer remains the leading cause of cancer-related mortality worldwide, posing a substantial global health burden. Despite advances in early detection, molecular profiling, and targeted therapies, patient outcomes remain unsatisfactory due to tumor heterogeneity, therapeutic resistance, and the lack of reliable preclinical models. In recent years, lung cancer organoids (LCOs), patient-derived three-dimensional (3D) culture systems, have demonstrated the ability to preserve the histological architecture and genomic features of primary tumors more faithfully than conventional models, making them a promising platform for translational research and precision medicine. This study aims to quantitatively evaluate the global research output, identify major contributors and collaboration patterns, and systematically uncover research hotspots and emerging trends in the field of LCOs through bibliometric analysis.
METHODS: A systematic bibliometric analysis was conducted using publications on LCOs retrieved from the Web of Science Core Collection (WoSCC). Articles published between 2015 and 2024 were included. A total of 356 publications were analyzed. Publication outputs, country and institutional contributions, collaboration networks, and keyword co-occurrence were evaluated using Bibliometrix (R package), VOSviewer, and CiteSpace.
RESULTS: The number of publications on LCOs has increased steadily over the past decade, reflecting growing research interest and technological advancement. China and the United States were identified as the leading contributors, accounting for the majority of publications, while Germany, South Korea, and Japan also demonstrated strong research capacity and active collaboration. Keyword and thematic analyses revealed several major research hotspots, including personalized medicine, drug response and resistance mechanisms, tumor microenvironment modeling, and immune-related interactions. Burst keyword analysis further identified emerging trends, such as co-culture systems, immunotherapy evaluation, and the integration of LCOs with high-throughput screening and multi-omics approaches.
CONCLUSIONS: LCOs have evolved into a versatile platform bridging basic research and clinical applications in lung cancer. This study provides a comprehensive overview of the current research landscape and highlights emerging directions in the field. Future research should focus on methodological standardization, optimization of organoid construction and evaluation, integration with multi-omics and immune models, and strengthened international collaboration to facilitate clinical translation and improve patient outcomes.
PMID:42182656 | PMC:PMC13190222 | DOI:10.21037/jtd-2026-0547
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Oncogene - Issue - nature.com science feeds
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Lactic acid induces dendritic cell pyroptosis through MCT-1 to promote tumor immune evasion
Oncogene, Published online: 23 May 2026; doi:10.1038/s41388-026-03825-6Lactic acid induces dendritic cell pyroptosis through MCT-1 to promote tumor immune evasion
Lactic acid induces dendritic cell pyroptosis through MCT-1 to promote tumor immune evasion
Oncogene, Published online: 23 May 2026; doi:10.1038/s41388-026-03825-6
Lactic acid induces dendritic cell pyroptosis through MCT-1 to promote tumor immune evasion-
npj Digital Medicine
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Decipher-MR: a vision-language foundation model for 3D MRI representations
npj Digital Medicine, Published online: 04 April 2026; doi:10.1038/s41746-026-02596-4Decipher-MR: a vision-language foundation model for 3D MRI representations
Decipher-MR: a vision-language foundation model for 3D MRI representations
npj Digital Medicine, Published online: 04 April 2026; doi:10.1038/s41746-026-02596-4
Decipher-MR: a vision-language foundation model for 3D MRI representations-
cs.AI, q-bio.NC updates on arXiv.org
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MOON3.0: Reasoning-aware Multimodal Representation Learning for E-commerce Product Understanding
arXiv:2604.00513v2 Announce Type: replace-cross Abstract: With the rapid growth of e-commerce, exploring general representations rather than task-specific ones has attracted increasing attention. Although recent multimodal large language models (MLLMs) have driven significant progress in product understanding, they are typically employed as feature extractors that implicitly encode product information into global embeddings, thereby limiting their ability to capture fine-grained attributes. The
MOON3.0: Reasoning-aware Multimodal Representation Learning for E-commerce Product Understanding
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cs.AI, q-bio.NC updates on arXiv.org
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MOON2.0: Dynamic Modality-balanced Multimodal Representation Learning for E-commerce Product Understanding
arXiv:2511.12449v2 Announce Type: replace-cross Abstract: Recent Multimodal Large Language Models (MLLMs) have significantly advanced e-commerce product understanding. However, they still face three challenges: (i) the modality imbalance induced by modality mixed training; (ii) underutilization of the intrinsic alignment relationships among visual and textual information within a product; and (iii) limited handling of noise in e-commerce multimodal data. To address these, we propose MOON2.0, a
MOON2.0: Dynamic Modality-balanced Multimodal Representation Learning for E-commerce Product Understanding
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cs.AI, q-bio.NC updates on arXiv.org
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TRACE: A Multi-Agent System for Autonomous Physical Reasoning in Seismological
arXiv:2603.21152v2 Announce Type: replace-cross Abstract: Inferring the physical mechanisms that govern earthquake sequences from indirect geophysical observations remains difficult, particularly across tectonically distinct environments where similar seismic patterns can reflect different underlying processes. Current interpretations rely heavily on the expert synthesis of catalogs, spatiotemporal statistics, and candidate physical models, limiting reproducibility and the systematic transfer o
TRACE: A Multi-Agent System for Autonomous Physical Reasoning in Seismological
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cs.AI, q-bio.NC updates on arXiv.org
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Variational Learning of Gaussian Process Latent Variable Models through Stochastic Gradient Annealed Importance Sampling
arXiv:2408.06710v3 Announce Type: replace-cross Abstract: Gaussian Process Latent Variable Models (GPLVMs) have become increasingly popular for unsupervised tasks such as dimensionality reduction and missing data recovery due to their flexibility and non-linear nature. An importance-weighted version of the Bayesian GPLVMs has been proposed to obtain a tighter variational bound. However, this version of the approach is primarily limited to analyzing simple data structures, as the generation of a
Variational Learning of Gaussian Process Latent Variable Models through Stochastic Gradient Annealed Importance Sampling
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cs.AI, q-bio.NC updates on arXiv.org
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ATPO: Adaptive Tree Policy Optimization for Multi-Turn Medical Dialogue
arXiv:2603.02216v1 Announce Type: cross Abstract: Effective information seeking in multi-turn medical dialogues is critical for accurate diagnosis, especially when dealing with incomplete information. Aligning Large Language Models (LLMs) for these interactive scenarios is challenging due to the uncertainty inherent in user-agent interactions, which we formulate as a Hierarchical Markov Decision Process (H-MDP). While conventional Reinforcement Learning (RL) methods like Group Relative Policy O
ATPO: Adaptive Tree Policy Optimization for Multi-Turn Medical Dialogue
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cs.AI, q-bio.NC updates on arXiv.org
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Enhancing Generative Auto-bidding with Offline Reward Evaluation and Policy Search
arXiv:2509.15927v4 Announce Type: replace-cross Abstract: Auto-bidding is a critical tool for advertisers to improve advertising performance. Recent progress has demonstrated that AI-Generated Bidding (AIGB), which learns a conditional generative planner from offline data, achieves superior performance compared to typical offline reinforcement learning (RL)-based auto-bidding methods. However, existing AIGB methods still face a performance bottleneck due to their inherent inability to explore b
Enhancing Generative Auto-bidding with Offline Reward Evaluation and Policy Search
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cs.AI, q-bio.NC updates on arXiv.org
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RAIR: A Rule-Aware Benchmark Uniting Challenging Long-Tail and Visual Salience Subset for E-commerce Relevance Assessment
arXiv:2512.24943v2 Announce Type: replace-cross Abstract: Search relevance plays a central role in web e-commerce. While large language models (LLMs) have shown significant results on relevance task, existing benchmarks lack sufficient complexity for comprehensive model assessment, resulting in an absence of standardized relevance evaluation metrics across the industry. To address this limitation, we propose Rule-Aware benchmark with Image for Relevance assessment(RAIR), a Chinese dataset deriv
RAIR: A Rule-Aware Benchmark Uniting Challenging Long-Tail and Visual Salience Subset for E-commerce Relevance Assessment
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cs.AI, q-bio.NC updates on arXiv.org
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Making Slow Thinking Faster: Compressing LLM Chain-of-Thought via Step Entropy
arXiv:2508.03346v2 Announce Type: replace Abstract: Large Language Models (LLMs) using Chain-of-Thought (CoT) prompting excel at complex reasoning but generate verbose thought processes with considerable redundancy, leading to increased inference costs and reduced efficiency. We introduce a novel CoT compression framework based on step entropy, a metric that quantifies \emph{the informational contribution of individual reasoning steps} to identify redundancy. Through theoretical analysis and ex