Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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Diagnosing Retrieval Bias Under Multiple In-Context Knowledge Updates in Large Language Models
arXiv:2603.12271v1 Announce Type: cross Abstract: LLMs are widely used in knowledge-intensive tasks where the same fact may be revised multiple times within context. Unlike prior work focusing on one-shot updates or single conflicts, multi-update scenarios contain multiple historically valid versions that compete at retrieval, yet remain underexplored. This challenge resembles the AB-AC interference paradigm in cognitive psychology: when the same cue A is successively associated with B and C, t
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cs.AI, q-bio.NC updates on arXiv.org
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SRAM-Based Compute-in-Memory Accelerator for Linear-decay Spiking Neural Networks
arXiv:2603.12739v1 Announce Type: cross Abstract: Spiking Neural Networks (SNNs) have emerged as a biologically inspired alternative to conventional deep networks, offering event-driven and energy-efficient computation. However, their throughput remains constrained by the serial update of neuron membrane states. While many hardware accelerators and Compute-in-Memory (CIM) architectures efficiently parallelize the synaptic operation (W x I) achieving O(1) complexity for matrix-vector multiplicat
SRAM-Based Compute-in-Memory Accelerator for Linear-decay Spiking Neural Networks
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cs.AI, q-bio.NC updates on arXiv.org
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SortScrews: A Dataset and Baseline for Real-time Screw Classification
arXiv:2603.13027v1 Announce Type: cross Abstract: Automatic identification of screw types is important for industrial automation, robotics, and inventory management. However, publicly available datasets for screw classification are scarce, particularly for controlled single-object scenarios commonly encountered in automated sorting systems. In this work, we introduce $\textbf{SortScrews}$, a dataset for casewise visual classification of screws. The dataset contains 560 RGB images at $512\times5
SortScrews: A Dataset and Baseline for Real-time Screw Classification
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cs.AI, q-bio.NC updates on arXiv.org
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VideoTemp-o3: Harmonizing Temporal Grounding and Video Understanding in Agentic Thinking-with-Videos
arXiv:2602.07801v3 Announce Type: replace-cross Abstract: In long-video understanding, conventional uniform frame sampling often fails to capture key visual evidence, leading to degraded performance and increased hallucinations. To address this, recent agentic thinking-with-videos paradigms have emerged, adopting a localize-clip-answer pipeline in which the model actively identifies relevant video segments, performs dense sampling within those clips, and then produces answers. However, existing
VideoTemp-o3: Harmonizing Temporal Grounding and Video Understanding in Agentic Thinking-with-Videos
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cs.AI, q-bio.NC updates on arXiv.org
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BitDance: Scaling Autoregressive Generative Models with Binary Tokens
arXiv:2602.14041v2 Announce Type: replace-cross Abstract: We present BitDance, a scalable autoregressive (AR) image generator that predicts binary visual tokens instead of codebook indices. With high-entropy binary latents, BitDance lets each token represent up to $2^{256}$ states, yielding a compact yet highly expressive discrete representation. Sampling from such a huge token space is difficult with standard classification. To resolve this, BitDance uses a binary diffusion head: instead of pr
BitDance: Scaling Autoregressive Generative Models with Binary Tokens
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Oncogene - Issue - nature.com science feeds
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LINC-AC092535.5 regulates MICAL2 mRNA level to inhibit p53-mediated ferroptosis in nasopharyngeal carcinoma
Oncogene, Published online: 14 March 2026; doi:10.1038/s41388-026-03714-yLINC-AC092535.5 regulates MICAL2 mRNA level to inhibit p53-mediated ferroptosis in nasopharyngeal carcinoma
LINC-AC092535.5 regulates MICAL2 mRNA level to inhibit p53-mediated ferroptosis in nasopharyngeal carcinoma
Oncogene, Published online: 14 March 2026; doi:10.1038/s41388-026-03714-y
LINC-AC092535.5 regulates MICAL2 mRNA level to inhibit p53-mediated ferroptosis in nasopharyngeal carcinoma-
(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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Multi-Omics Characterization of Lactate-Associated Molecular Subtypes in Lung Cancer Suggests a Role for DKK1 in Lactate-Linked Migration, Invasion, and Lactylation Programs
Cancers (Basel). 2026 Feb 25;18(5):735. doi: 10.3390/cancers18050735.ABSTRACTBACKGROUND: Lactate accumulation is increasingly recognized as a feature of tumor metabolic reprogramming that can coincide with immune dysregulation and aggressive phenotypes. The prognostic and immunologic relevance of lactate-associated heterogeneity in lung cancer remains to be clarified.METHODS: We curated lactate-related genes and identified prognostic candidates in lung cancer cohorts. Consensus clustering was ap
Multi-Omics Characterization of Lactate-Associated Molecular Subtypes in Lung Cancer Suggests a Role for DKK1 in Lactate-Linked Migration, Invasion, and Lactylation Programs
Cancers (Basel). 2026 Feb 25;18(5):735. doi: 10.3390/cancers18050735.
ABSTRACT
BACKGROUND: Lactate accumulation is increasingly recognized as a feature of tumor metabolic reprogramming that can coincide with immune dysregulation and aggressive phenotypes. The prognostic and immunologic relevance of lactate-associated heterogeneity in lung cancer remains to be clarified.
METHODS: We curated lactate-related genes and identified prognostic candidates in lung cancer cohorts. Consensus clustering was applied to define lactate-associated molecular subtypes, followed by characterization of survival and tumor microenvironment features. A LASSO-based gene signature was developed to generate an individual-level risk score and an integrated nomogram. Multi-omics analyses were used to evaluate concordance between transcriptomic and proteomic alterations. Single-cell transcriptomic data were analyzed to explore cellular heterogeneity in lactate-related programs. In vitro assays evaluated the response of candidate genes to lactate exposure and assessed cell migration and invasion under proliferation-inhibited conditions after genetic perturbation.
RESULTS: Two lactate-associated molecular subtypes were identified with distinct overall survival and divergent immune microenvironment features. Subtype 1 was associated with better outcomes and a more immune-inflamed profile, whereas Subtype 2 was associated with poorer outcomes and a myeloid-enriched, immunosuppressive contexture. Pathway analyses indicated subtype-associated differences in extracellular matrix-related processes and apoptosis-associated signaling. We developed an 11-gene prognostic signature and nomogram that stratified patients by risk across TCGA and GEO cohorts. Multi-omics integration highlighted ANLN, FGA, and DKK1 as consistently dysregulated at both transcript and protein levels. Among these candidates, DKK1 showed lactate-responsive induction in vitro. DKK1 perturbation altered lactate-enhanced migratory and invasive phenotypes and was accompanied by changes in intracellular lactate levels and global protein lactylation, supporting a potential feedforward relationship between lactate exposure, DKK1 expression, and lactylation.
CONCLUSIONS: This study characterizes lactate-associated molecular heterogeneity in lung cancer and provides a lactate-related subtype framework and prognostic risk model for patient stratification. The findings nominate DKK1 as a lactate-responsive candidate linked to migration/invasion phenotypes and lactate/lactylation changes in vitro.
PMID:41827671 | PMC:PMC12985219 | DOI:10.3390/cancers18050735
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(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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Diverse genomic and transcriptomic heterogeneity in EGFR-mutant lung adenocarcinoma between exon 19 del and exon 21 L858R
Cell Commun Signal. 2026 Mar 14. doi: 10.1186/s12964-026-02793-4. Online ahead of print.NO ABSTRACTPMID:41826981 | DOI:10.1186/s12964-026-02793-4
Diverse genomic and transcriptomic heterogeneity in EGFR-mutant lung adenocarcinoma between exon 19 del and exon 21 L858R
Cell Commun Signal. 2026 Mar 14. doi: 10.1186/s12964-026-02793-4. Online ahead of print.
NO ABSTRACT
PMID:41826981 | DOI:10.1186/s12964-026-02793-4
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Omics In Lung
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Multi-Omics Characterization of Lactate-Associated Molecular Subtypes in Lung Cancer Suggests a Role for DKK1 in Lactate-Linked Migration, Invasion, and Lactylation Programs
Cancers (Basel). 2026 Feb 25;18(5):735. doi: 10.3390/cancers18050735.ABSTRACTBACKGROUND: Lactate accumulation is increasingly recognized as a feature of tumor metabolic reprogramming that can coincide with immune dysregulation and aggressive phenotypes. The prognostic and immunologic relevance of lactate-associated heterogeneity in lung cancer remains to be clarified.METHODS: We curated lactate-related genes and identified prognostic candidates in lung cancer cohorts. Consensus clustering was ap
Multi-Omics Characterization of Lactate-Associated Molecular Subtypes in Lung Cancer Suggests a Role for DKK1 in Lactate-Linked Migration, Invasion, and Lactylation Programs
Cancers (Basel). 2026 Feb 25;18(5):735. doi: 10.3390/cancers18050735.
ABSTRACT
BACKGROUND: Lactate accumulation is increasingly recognized as a feature of tumor metabolic reprogramming that can coincide with immune dysregulation and aggressive phenotypes. The prognostic and immunologic relevance of lactate-associated heterogeneity in lung cancer remains to be clarified.
METHODS: We curated lactate-related genes and identified prognostic candidates in lung cancer cohorts. Consensus clustering was applied to define lactate-associated molecular subtypes, followed by characterization of survival and tumor microenvironment features. A LASSO-based gene signature was developed to generate an individual-level risk score and an integrated nomogram. Multi-omics analyses were used to evaluate concordance between transcriptomic and proteomic alterations. Single-cell transcriptomic data were analyzed to explore cellular heterogeneity in lactate-related programs. In vitro assays evaluated the response of candidate genes to lactate exposure and assessed cell migration and invasion under proliferation-inhibited conditions after genetic perturbation.
RESULTS: Two lactate-associated molecular subtypes were identified with distinct overall survival and divergent immune microenvironment features. Subtype 1 was associated with better outcomes and a more immune-inflamed profile, whereas Subtype 2 was associated with poorer outcomes and a myeloid-enriched, immunosuppressive contexture. Pathway analyses indicated subtype-associated differences in extracellular matrix-related processes and apoptosis-associated signaling. We developed an 11-gene prognostic signature and nomogram that stratified patients by risk across TCGA and GEO cohorts. Multi-omics integration highlighted ANLN, FGA, and DKK1 as consistently dysregulated at both transcript and protein levels. Among these candidates, DKK1 showed lactate-responsive induction in vitro. DKK1 perturbation altered lactate-enhanced migratory and invasive phenotypes and was accompanied by changes in intracellular lactate levels and global protein lactylation, supporting a potential feedforward relationship between lactate exposure, DKK1 expression, and lactylation.
CONCLUSIONS: This study characterizes lactate-associated molecular heterogeneity in lung cancer and provides a lactate-related subtype framework and prognostic risk model for patient stratification. The findings nominate DKK1 as a lactate-responsive candidate linked to migration/invasion phenotypes and lactate/lactylation changes in vitro.
PMID:41827671 | PMC:PMC12985219 | DOI:10.3390/cancers18050735
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Oncogenesis - nature.com science feeds
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Inhibition of ZBTB7B-mediated ADPGK transcription by NEDD4 impedes glycolysis and progression of lung adenocarcinoma
Oncogenesis, Published online: 11 March 2026; doi:10.1038/s41389-026-00605-5Inhibition of ZBTB7B-mediated ADPGK transcription by NEDD4 impedes glycolysis and progression of lung adenocarcinoma
Inhibition of ZBTB7B-mediated ADPGK transcription by NEDD4 impedes glycolysis and progression of lung adenocarcinoma
Oncogenesis, Published online: 11 March 2026; doi:10.1038/s41389-026-00605-5
Inhibition of ZBTB7B-mediated ADPGK transcription by NEDD4 impedes glycolysis and progression of lung adenocarcinoma-
cs.AI, q-bio.NC updates on arXiv.org
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Better Eyes, Better Thoughts: Why Vision Chain-of-Thought Fails in Medicine
arXiv:2603.06665v1 Announce Type: cross Abstract: Large vision-language models (VLMs) often benefit from chain-of-thought (CoT) prompting in general domains, yet its efficacy in medical vision-language tasks remains underexplored. We report a counter-intuitive trend: on medical visual question answering, CoT frequently underperforms direct answering (DirA) across general-purpose and medical-specific models. We attribute this to a \emph{medical perception bottleneck}: subtle, domain-specific cue
Better Eyes, Better Thoughts: Why Vision Chain-of-Thought Fails in Medicine
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cs.AI, q-bio.NC updates on arXiv.org
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Revealing Behavioral Plasticity in Large Language Models: A Token-Conditional Perspective
arXiv:2603.08398v1 Announce Type: cross Abstract: In this work, we reveal that Large Language Models (LLMs) possess intrinsic behavioral plasticity-akin to chameleons adapting their coloration to environmental cues-that can be exposed through token-conditional generation and stabilized via reinforcement learning. Specifically, by conditioning generation on carefully selected token prefixes sampled from responses exhibiting desired behaviors, LLMs seamlessly adapt their behavioral modes at infer
Revealing Behavioral Plasticity in Large Language Models: A Token-Conditional Perspective
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cs.AI, q-bio.NC updates on arXiv.org
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Batch-of-Thought: Cross-Instance Learning for Enhanced LLM Reasoning
arXiv:2601.02950v2 Announce Type: replace Abstract: Current Large Language Model reasoning systems process queries independently, discarding valuable cross-instance signals such as shared reasoning patterns and consistency constraints. We introduce Batch-of-Thought (BoT), a training-free method that processes related queries jointly to enable cross-instance learning. By performing comparative analysis across batches, BoT identifies high-quality reasoning templates, detects errors through consis
Batch-of-Thought: Cross-Instance Learning for Enhanced LLM Reasoning
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cs.AI, q-bio.NC updates on arXiv.org
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Multimodal Laryngoscopic Video Analysis for Assisted Diagnosis of Vocal Fold Paralysis
arXiv:2409.03597v4 Announce Type: replace-cross Abstract: This paper presents the Multimodal Laryngoscopic Video Analyzing System (MLVAS), a novel system that leverages both audio and video data to automatically extract key video segments and metrics from raw laryngeal videostroboscopic videos for assisted clinical assessment. The system integrates video-based glottis detection with an audio keyword spotting method to analyze both video and audio data, identifying patient vocalizations and refi
Multimodal Laryngoscopic Video Analysis for Assisted Diagnosis of Vocal Fold Paralysis
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cs.AI, q-bio.NC updates on arXiv.org
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OTESGN: Optimal Transport-Enhanced Syntactic-Semantic Graph Networks for Aspect-Based Sentiment Analysis
arXiv:2509.08612v3 Announce Type: replace-cross Abstract: Aspect-based sentiment analysis (ABSA) aims to identify aspect terms and determine their sentiment polarity. While dependency trees combined with contextual semantics provide structural cues, existing approaches often rely on dot-product similarity and fixed graphs, which limit their ability to capture nonlinear associations and adapt to noisy contexts. To address these limitations, we propose the Optimal Transport-Enhanced Syntactic-Sem
OTESGN: Optimal Transport-Enhanced Syntactic-Semantic Graph Networks for Aspect-Based Sentiment Analysis
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cs.AI, q-bio.NC updates on arXiv.org
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TTSR: Test-Time Self-Reflection for Continual Reasoning Improvement
arXiv:2603.03297v1 Announce Type: cross Abstract: Test-time Training enables model adaptation using only test questions and offers a promising paradigm for improving the reasoning ability of large language models (LLMs). However, it faces two major challenges: test questions are often highly difficult, making self-generated pseudo-labels unreliable, and existing methods lack effective mechanisms to adapt to a model's specific reasoning weaknesses, leading to inefficient learning. To address the
TTSR: Test-Time Self-Reflection for Continual Reasoning Improvement
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cs.AI, q-bio.NC updates on arXiv.org
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Local Shapley: Model-Induced Locality and Optimal Reuse in Data Valuation
arXiv:2603.03672v1 Announce Type: cross Abstract: The Shapley value provides a principled foundation for data valuation, but exact computation is #P-hard due to the exponential coalition space. Existing accelerations remain global and ignore a structural property of modern predictors: for a given test instance, only a small subset of training points influences the prediction. We formalize this model-induced locality through support sets defined by the model's computational pathway (e.g., neighb
Local Shapley: Model-Induced Locality and Optimal Reuse in Data Valuation
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cs.AI, q-bio.NC updates on arXiv.org
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Agent Data Protocol: Unifying Datasets for Diverse, Effective Fine-tuning of LLM Agents
arXiv:2510.24702v2 Announce Type: replace-cross Abstract: Public research results on large-scale supervised finetuning of AI agents remain relatively rare, since the collection of agent training data presents unique challenges. In this work, we argue that the bottleneck is not a lack of underlying data sources, but that a large variety of data is fragmented across heterogeneous formats, tools, and interfaces. To this end, we introduce the agent data protocol (ADP), a light-weight representation
Agent Data Protocol: Unifying Datasets for Diverse, Effective Fine-tuning of LLM Agents
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cs.AI, q-bio.NC updates on arXiv.org
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Weight Space Representation Learning via Neural Field Adaptation
arXiv:2512.01759v2 Announce Type: replace-cross Abstract: In this work, we investigate the potential of weights to serve as effective representations, focusing on neural fields. Our key insight is that constraining the optimization space through a pre-trained base model and low-rank adaptation (LoRA) can induce structure in weight space. Across reconstruction, generation, and analysis tasks on 2D and 3D data, we find that multiplicative LoRA weights achieve high representation quality while exh
Weight Space Representation Learning via Neural Field Adaptation
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cs.AI, q-bio.NC updates on arXiv.org
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UniG2U-Bench: Do Unified Models Advance Multimodal Understanding?
arXiv:2603.03241v1 Announce Type: cross Abstract: Unified multimodal models have recently demonstrated strong generative capabilities, yet whether and when generation improves understanding remains unclear. Existing benchmarks lack a systematic exploration of the specific tasks where generation facilitates understanding. To this end, we introduce UniG2U-Bench, a comprehensive benchmark categorizing generation-to-understanding (G2U) evaluation into 7 regimes and 30 subtasks, requiring varying de